diff --git a/wgpu-core/src/command/compute.rs b/wgpu-core/src/command/compute.rs
index 7f396d11b..1540a5f50 100644
--- a/wgpu-core/src/command/compute.rs
+++ b/wgpu-core/src/command/compute.rs
@@ -136,6 +136,8 @@ pub enum ComputePassErrorInner {
     BindGroupIndexOutOfRange { index: u32, max: u32 },
     #[error(transparent)]
     DestroyedResource(#[from] DestroyedResourceError),
+    #[error("Indirect buffer offset {0:?} is not a multiple of 4")]
+    UnalignedIndirectBufferOffset(BufferAddress),
     #[error("Indirect buffer uses bytes {offset}..{end_offset} which overruns indirect buffer of size {buffer_size}")]
     IndirectBufferOverrun {
         offset: u64,
@@ -845,6 +847,10 @@ fn dispatch_indirect(
         .merge_single(&buffer, hal::BufferUses::INDIRECT)?;
     buffer.check_usage(wgt::BufferUsages::INDIRECT)?;
 
+    if offset % 4 != 0 {
+        return Err(ComputePassErrorInner::UnalignedIndirectBufferOffset(offset));
+    }
+
     let end_offset = offset + size_of::<wgt::DispatchIndirectArgs>() as u64;
     if end_offset > buffer.size {
         return Err(ComputePassErrorInner::IndirectBufferOverrun {
diff --git a/wgpu-core/src/command/render.rs b/wgpu-core/src/command/render.rs
index b6680333c..d22eb5f0d 100644
--- a/wgpu-core/src/command/render.rs
+++ b/wgpu-core/src/command/render.rs
@@ -638,6 +638,8 @@ pub enum RenderPassErrorInner {
     MissingFeatures(#[from] MissingFeatures),
     #[error(transparent)]
     MissingDownlevelFlags(#[from] MissingDownlevelFlags),
+    #[error("Indirect buffer offset {0:?} is not a multiple of 4")]
+    UnalignedIndirectBufferOffset(BufferAddress),
     #[error("Indirect draw uses bytes {offset}..{end_offset} {} which overruns indirect buffer of size {buffer_size}",
         count.map_or_else(String::new, |v| format!("(using count {v})")))]
     IndirectBufferOverrun {
@@ -2450,6 +2452,10 @@ fn multi_draw_indirect(
 
     let actual_count = count.map_or(1, |c| c.get());
 
+    if offset % 4 != 0 {
+        return Err(RenderPassErrorInner::UnalignedIndirectBufferOffset(offset));
+    }
+
     let end_offset = offset + stride as u64 * actual_count as u64;
     if end_offset > indirect_buffer.size {
         return Err(RenderPassErrorInner::IndirectBufferOverrun {
@@ -2534,6 +2540,10 @@ fn multi_draw_indirect_count(
     count_buffer.check_usage(BufferUsages::INDIRECT)?;
     let count_raw = count_buffer.try_raw(state.snatch_guard)?;
 
+    if offset % 4 != 0 {
+        return Err(RenderPassErrorInner::UnalignedIndirectBufferOffset(offset));
+    }
+
     let end_offset = offset + stride * max_count as u64;
     if end_offset > indirect_buffer.size {
         return Err(RenderPassErrorInner::IndirectBufferOverrun {