diff --git a/compiler/rustc_codegen_ssa/src/mir/block.rs b/compiler/rustc_codegen_ssa/src/mir/block.rs
index 71c71d59b7a..40a06098c5a 100644
--- a/compiler/rustc_codegen_ssa/src/mir/block.rs
+++ b/compiler/rustc_codegen_ssa/src/mir/block.rs
@@ -1482,7 +1482,11 @@ impl<'a, 'tcx, Bx: BuilderMethods<'a, 'tcx>> FunctionCx<'a, 'tcx, Bx> {
     ) -> OperandRef<'tcx, Bx::Value> {
         let tcx = bx.tcx();
 
-        let mut span_to_caller_location = |span: Span| {
+        let mut span_to_caller_location = |mut span: Span| {
+            // Remove `Inlined` marks as they pollute `expansion_cause`.
+            while span.is_inlined() {
+                span.remove_mark();
+            }
             let topmost = span.ctxt().outer_expn().expansion_cause().unwrap_or(span);
             let caller = tcx.sess.source_map().lookup_char_pos(topmost.lo());
             let const_loc = tcx.const_caller_location((
diff --git a/compiler/rustc_const_eval/src/interpret/intrinsics/caller_location.rs b/compiler/rustc_const_eval/src/interpret/intrinsics/caller_location.rs
index cf52299b7ba..76c8d0a975a 100644
--- a/compiler/rustc_const_eval/src/interpret/intrinsics/caller_location.rs
+++ b/compiler/rustc_const_eval/src/interpret/intrinsics/caller_location.rs
@@ -111,7 +111,11 @@ impl<'mir, 'tcx: 'mir, M: Machine<'mir, 'tcx>> InterpCx<'mir, 'tcx, M> {
         location
     }
 
-    pub(crate) fn location_triple_for_span(&self, span: Span) -> (Symbol, u32, u32) {
+    pub(crate) fn location_triple_for_span(&self, mut span: Span) -> (Symbol, u32, u32) {
+        // Remove `Inlined` marks as they pollute `expansion_cause`.
+        while span.is_inlined() {
+            span.remove_mark();
+        }
         let topmost = span.ctxt().outer_expn().expansion_cause().unwrap_or(span);
         let caller = self.tcx.sess.source_map().lookup_char_pos(topmost.lo());
         (
diff --git a/compiler/rustc_span/src/hygiene.rs b/compiler/rustc_span/src/hygiene.rs
index 9f22e9776d4..d727aba6de5 100644
--- a/compiler/rustc_span/src/hygiene.rs
+++ b/compiler/rustc_span/src/hygiene.rs
@@ -880,7 +880,7 @@ impl Span {
     pub fn fresh_expansion(self, expn_id: LocalExpnId) -> Span {
         HygieneData::with(|data| {
             self.with_ctxt(data.apply_mark(
-                SyntaxContext::root(),
+                self.ctxt(),
                 expn_id.to_expn_id(),
                 Transparency::Transparent,
             ))
diff --git a/tests/ui/rfc-2091-track-caller/intrinsic-wrapper.rs b/tests/ui/rfc-2091-track-caller/intrinsic-wrapper.rs
index 87e52881c15..23d2a4b0a99 100644
--- a/tests/ui/rfc-2091-track-caller/intrinsic-wrapper.rs
+++ b/tests/ui/rfc-2091-track-caller/intrinsic-wrapper.rs
@@ -1,5 +1,6 @@
 // run-pass
 // revisions: default mir-opt
+//[default] compile-flags: -Zinline-mir=no
 //[mir-opt] compile-flags: -Zmir-opt-level=4
 
 macro_rules! caller_location_from_macro {
@@ -9,13 +10,13 @@ macro_rules! caller_location_from_macro {
 fn main() {
     let loc = core::panic::Location::caller();
     assert_eq!(loc.file(), file!());
-    assert_eq!(loc.line(), 10);
+    assert_eq!(loc.line(), 11);
     assert_eq!(loc.column(), 15);
 
     // `Location::caller()` in a macro should behave similarly to `file!` and `line!`,
     // i.e. point to where the macro was invoked, instead of the macro itself.
     let loc2 = caller_location_from_macro!();
     assert_eq!(loc2.file(), file!());
-    assert_eq!(loc2.line(), 17);
+    assert_eq!(loc2.line(), 18);
     assert_eq!(loc2.column(), 16);
 }
diff --git a/tests/ui/rfc-2091-track-caller/mir-inlined-macro.rs b/tests/ui/rfc-2091-track-caller/mir-inlined-macro.rs
new file mode 100644
index 00000000000..a2e8eb27ede
--- /dev/null
+++ b/tests/ui/rfc-2091-track-caller/mir-inlined-macro.rs
@@ -0,0 +1,23 @@
+// run-pass
+// revisions: default mir-opt
+//[default] compile-flags: -Zinline-mir=no
+//[mir-opt] compile-flags: -Zmir-opt-level=4
+
+use std::panic::Location;
+
+macro_rules! f {
+    () => {
+        Location::caller()
+    };
+}
+
+#[inline(always)]
+fn g() -> &'static Location<'static> {
+    f!()
+}
+
+fn main() {
+    let loc = g();
+    assert_eq!(loc.line(), 16);
+    assert_eq!(loc.column(), 5);
+}