diff --git a/pkgs/development/interpreters/python/cpython/default.nix b/pkgs/development/interpreters/python/cpython/default.nix
index 842d132fd44c..e9fdc638f6ae 100644
--- a/pkgs/development/interpreters/python/cpython/default.nix
+++ b/pkgs/development/interpreters/python/cpython/default.nix
@@ -40,7 +40,8 @@
 , static ? stdenv.hostPlatform.isStatic
 , enableOptimizations ? false
 # enableNoSemanticInterposition is a subset of the enableOptimizations flag that doesn't harm reproducibility.
-, enableNoSemanticInterposition ? true
+# clang starts supporting `-fno-sematic-interposition` with version 10
+, enableNoSemanticInterposition ? (!stdenv.cc.isClang || (stdenv.cc.isClang && lib.versionAtLeast stdenv.cc.version "10"))
 # enableLTO is a subset of the enableOptimizations flag that doesn't harm reproducibility.
 # enabling LTO on 32bit arch causes downstream packages to fail when linking
 , enableLTO ? stdenv.is64bit