diff --git a/pkgs/development/libraries/itk/generic.nix b/pkgs/development/libraries/itk/generic.nix
index 78f4d56bfac6..3a6b2afee0d9 100644
--- a/pkgs/development/libraries/itk/generic.nix
+++ b/pkgs/development/libraries/itk/generic.nix
@@ -3,10 +3,7 @@
 { lib, stdenv, fetchFromGitHub, cmake, makeWrapper
 , pkg-config, libX11, libuuid, xz, vtk, Cocoa }:
 
-stdenv.mkDerivation rec {
-  pname = "itk";
-  inherit version;
-
+let
   itkGenericLabelInterpolatorSrc = fetchFromGitHub {
     owner = "InsightSoftwareConsortium";
     repo = "ITKGenericLabelInterpolator";
@@ -21,6 +18,18 @@ stdenv.mkDerivation rec {
     hash = "sha256-deJbza36c0Ohf9oKpO2T4po37pkyI+2wCSeGL4r17Go=";
   };
 
+  itkSimpleITKFiltersSrc = fetchFromGitHub {
+    owner = "InsightSoftwareConsortium";
+    repo = "ITKSimpleITKFilters";
+    rev = "bb896868fc6480835495d0da4356d5db009592a6";
+    hash = "sha256-MfaIA0xxA/pzUBSwnAevr17iR23Bo5iQO2cSyknS3o4=";
+  };
+in
+
+stdenv.mkDerivation {
+  pname = "itk";
+  inherit version;
+
   src = fetchFromGitHub {
     owner = "InsightSoftwareConsortium";
     repo = "ITK";
@@ -36,6 +45,7 @@ stdenv.mkDerivation rec {
       --replace "@OPENJPEG_INSTALL_LIB_DIR@" "@OPENJPEG_INSTALL_FULL_LIB_DIR@"
     ln -sr ${itkGenericLabelInterpolatorSrc} Modules/External/ITKGenericLabelInterpolator
     ln -sr ${itkAdaptiveDenoisingSrc} Modules/External/ITKAdaptiveDenoising
+    ln -sr ${itkSimpleITKFiltersSrc} Modules/External/ITKSimpleITKFilters
   '';
 
   cmakeFlags = [
@@ -45,6 +55,7 @@ stdenv.mkDerivation rec {
     "-DModule_ITKMINC=ON"
     "-DModule_ITKIOMINC=ON"
     "-DModule_ITKIOTransformMINC=ON"
+    "-DModule_SimpleITKFilters=ON"
     "-DModule_ITKVtkGlue=ON"
     "-DModule_ITKReview=ON"
     "-DModule_MGHIO=ON"
@@ -69,7 +80,7 @@ stdenv.mkDerivation rec {
 
   meta = {
     description = "Insight Segmentation and Registration Toolkit";
-    homepage = "https://www.itk.org/";
+    homepage = "https://www.itk.org";
     license = lib.licenses.asl20;
     maintainers = with lib.maintainers; [viric];
   };
diff --git a/pkgs/development/libraries/simpleitk/default.nix b/pkgs/development/libraries/simpleitk/default.nix
index a09ac168ba46..88b1d1ade174 100644
--- a/pkgs/development/libraries/simpleitk/default.nix
+++ b/pkgs/development/libraries/simpleitk/default.nix
@@ -4,12 +4,10 @@ stdenv.mkDerivation rec {
   pname = "simpleitk";
   version = "2.2.1";
 
-  outputs = [ "out" "dev" ];
-
   src = fetchFromGitHub {
     owner = "SimpleITK";
     repo = "SimpleITK";
-    rev = "v${version}";
+    rev = "refs/tags/v${version}";
     hash = "sha256-0YxmixUTXpjegZQv7DDCNTWFTH8QEWqQQszee7aQ5EI=";
   };
 
diff --git a/pkgs/development/python-modules/simpleitk/default.nix b/pkgs/development/python-modules/simpleitk/default.nix
new file mode 100644
index 000000000000..cc138695e3fd
--- /dev/null
+++ b/pkgs/development/python-modules/simpleitk/default.nix
@@ -0,0 +1,27 @@
+{ lib
+, buildPythonPackage
+, pythonOlder
+, fetchFromGitHub
+, cmake
+, swig4
+, itk
+, numpy
+, simpleitk
+, scikit-build
+}:
+
+buildPythonPackage rec {
+  inherit (simpleitk) pname version src meta;
+  format = "pyproject";
+  disabled = pythonOlder "3.8";
+
+  sourceRoot = "source/Wrapping/Python";
+  preBuild = ''
+    make
+  '';
+
+  nativeBuildInputs = [ cmake swig4 scikit-build ];
+  propagatedBuildInputs = [ itk simpleitk numpy ];
+
+  pythonImportsCheck = [ "SimpleITK" ];
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index f2bb3202f356..2594f7e87272 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -10828,6 +10828,10 @@ self: super: with self; {
 
   simplehound = callPackage ../development/python-modules/simplehound { };
 
+  simpleitk = callPackage ../development/python-modules/simpleitk {
+    inherit (pkgs) simpleitk;
+  };
+
   simplejson = callPackage ../development/python-modules/simplejson { };
 
   simplekml = callPackage ../development/python-modules/simplekml { };