diff --git a/pkgs/build-support/cc-wrapper/default.nix b/pkgs/build-support/cc-wrapper/default.nix
index 33df804d5efe..2f3b2d8e3788 100644
--- a/pkgs/build-support/cc-wrapper/default.nix
+++ b/pkgs/build-support/cc-wrapper/default.nix
@@ -343,18 +343,11 @@ stdenv.mkDerivation {
     # compile, because it uses "#include_next <limits.h>" to find the
     # limits.h file in ../includes-fixed. To remedy the problem,
     # another -idirafter is necessary to add that directory again.
-    #
-    # We use --sysroot=/nix/store/does/not/exist to drop embedded default
-    # path to glibc headers gcc was built against. Without it -idirafter
-    # only appends to the list and outdated glibc headers end up being
-    # used. 'cc-cflags-before' is used to allow user's --sysroot= option
-    # to override our default.
     + optionalString (libc != null) (''
       touch "$out/nix-support/libc-cflags"
       touch "$out/nix-support/libc-ldflags"
       echo "-B${libc_lib}${libc.libdir or "/lib/"}" >> $out/nix-support/libc-crt1-cflags
     '' + optionalString (!(cc.langD or false)) ''
-      echo "--sysroot=/nix/store/does/not/exist" >> $out/nix-support/cc-cflags-before
       echo "-idirafter ${libc_dev}${libc.incdir or "/include"}" >> $out/nix-support/libc-cflags
     '' + optionalString (isGNU && (!(cc.langD or false))) ''
       for dir in "${cc}"/lib/gcc/*/*/include-fixed; do
diff --git a/pkgs/development/compilers/dmd/generic.nix b/pkgs/development/compilers/dmd/generic.nix
index c1fb9abf77d7..3f8871df4f96 100644
--- a/pkgs/development/compilers/dmd/generic.nix
+++ b/pkgs/development/compilers/dmd/generic.nix
@@ -151,13 +151,6 @@ stdenv.mkDerivation rec {
     git
   ];
 
-  # Workaround cc-wrapper's --sysroot= value for `staging-next`: it
-  # breaks library lookup via RUNPATH:
-  #   ld: warning: libm.so.6, needed by ./generated/linux/release/64/lib.so, not found (try using -rpath or -rpath-link)
-  #   ld: /build/druntime/generated/linux/release/64/libdruntime.so: undefined reference to `log10@GLIBC_2.2.5'
-  # TODO(trofi): remove the workaround once cc-wrapper is fixed.
-  NIX_CFLAGS_COMPILE = [ "--sysroot=/" ];
-
   buildInputs = [
     curl
     tzdata
diff --git a/pkgs/development/libraries/mesa/default.nix b/pkgs/development/libraries/mesa/default.nix
index 89526fbda7f4..2d47b090b1a8 100644
--- a/pkgs/development/libraries/mesa/default.nix
+++ b/pkgs/development/libraries/mesa/default.nix
@@ -322,10 +322,6 @@ self = stdenv.mkDerivation {
   NIX_CFLAGS_COMPILE = lib.optionals stdenv.isDarwin [ "-fno-common" ] ++ lib.optionals enableOpenCL [
     "-UPIPE_SEARCH_DIR"
     "-DPIPE_SEARCH_DIR=\"${placeholder "opencl"}/lib/gallium-pipe\""
-
-    # Work around regression from https://github.com/NixOS/nixpkgs/pull/210004
-    # TODO(trofi): remove
-    "--sysroot=/"
   ];
 
   passthru = {
diff --git a/pkgs/misc/uboot/default.nix b/pkgs/misc/uboot/default.nix
index 42d7021f3452..a36005872500 100644
--- a/pkgs/misc/uboot/default.nix
+++ b/pkgs/misc/uboot/default.nix
@@ -92,16 +92,6 @@ let
 
     passAsFile = [ "extraConfig" ];
 
-    # Workaround '-idirafter' ordering bug in staging-next:
-    #   https://github.com/NixOS/nixpkgs/pull/210004
-    # where libc '-idirafter' gets added after user's idirafter and
-    # breaks.
-    # TODO(trofi): remove it in staging once fixed in cc-wrapper.
-    preConfigure = ''
-      export NIX_CFLAGS_COMPILE_BEFORE_${lib.replaceStrings ["-" "."] ["_" "_"] buildPackages.stdenv.hostPlatform.config}=$(< ${buildPackages.stdenv.cc}/nix-support/libc-cflags)
-      export NIX_CFLAGS_COMPILE_BEFORE_${lib.replaceStrings ["-" "."] ["_" "_"]               stdenv.hostPlatform.config}=$(<               ${stdenv.cc}/nix-support/libc-cflags)
-    '';
-
     configurePhase = ''
       runHook preConfigure
 
diff --git a/pkgs/tools/misc/ipxe/default.nix b/pkgs/tools/misc/ipxe/default.nix
index 65c88eac4e88..c3a0c5aa906d 100644
--- a/pkgs/tools/misc/ipxe/default.nix
+++ b/pkgs/tools/misc/ipxe/default.nix
@@ -48,16 +48,6 @@ stdenv.mkDerivation rec {
     substituteInPlace src/util/genfsimg --replace "	syslinux " "	true "
   ''; # calling syslinux on a FAT image isn't going to work
 
-  # Workaround '-idirafter' ordering bug in staging-next:
-  #   https://github.com/NixOS/nixpkgs/pull/210004
-  # where libc '-idirafter' gets added after user's idirafter and
-  # breaks.
-  # TODO(trofi): remove it in staging once fixed in cc-wrapper.
-  preConfigure = ''
-    export NIX_CFLAGS_COMPILE_BEFORE_${lib.replaceStrings ["-" "."] ["_" "_"] buildPackages.stdenv.hostPlatform.config}=$(< ${buildPackages.stdenv.cc}/nix-support/libc-cflags)
-    export NIX_CFLAGS_COMPILE_BEFORE_${lib.replaceStrings ["-" "."] ["_" "_"]               stdenv.hostPlatform.config}=$(<               ${stdenv.cc}/nix-support/libc-cflags)
-  '';
-
   # not possible due to assembler code
   hardeningDisable = [ "pic" "stackprotector" ];
 
diff --git a/pkgs/tools/misc/wimboot/default.nix b/pkgs/tools/misc/wimboot/default.nix
index 71f31c720d02..bc43d77bbfba 100644
--- a/pkgs/tools/misc/wimboot/default.nix
+++ b/pkgs/tools/misc/wimboot/default.nix
@@ -13,15 +13,6 @@ stdenv.mkDerivation rec {
 
   sourceRoot = "source/src";
 
-  # Workaround '-idirafter' ordering bug in staging-next:
-  #   https://github.com/NixOS/nixpkgs/pull/210004
-  # where libc '-idirafter' gets added after user's idirafter and
-  # breaks.
-  # TODO(trofi): remove it in staging once fixed in cc-wrapper.
-  preConfigure = ''
-    export NIX_CFLAGS_COMPILE_BEFORE_${lib.replaceStrings ["-" "."] ["_" "_"] stdenv.hostPlatform.config}=$(< ${stdenv.cc}/nix-support/libc-cflags)
-  '';
-
   buildInputs = [ libbfd zlib libiberty ];
   makeFlags = [ "wimboot.x86_64.efi" ];