diff --git a/pkgs/tools/networking/vpn-slice/default.nix b/pkgs/tools/networking/vpn-slice/default.nix
index 3d883dca5b11..3fb921bb44b8 100644
--- a/pkgs/tools/networking/vpn-slice/default.nix
+++ b/pkgs/tools/networking/vpn-slice/default.nix
@@ -1,4 +1,13 @@
-{ lib, buildPythonApplication, nix-update-script, python3Packages, fetchFromGitHub }:
+{ lib
+, stdenv
+, buildPythonApplication
+, nix-update-script
+, python3Packages
+, fetchFromGitHub
+, iproute2
+, iptables
+, unixtools
+}:
 
 buildPythonApplication rec {
   pname = "vpn-slice";
@@ -11,6 +20,15 @@ buildPythonApplication rec {
     sha256 = "sha256-T6VULLNRLWO4OcAsuTmhty6H4EhinyxQSg0dfv2DUJs=";
   };
 
+  postPatch = lib.optionalString stdenv.isDarwin ''
+    substituteInPlace vpn_slice/mac.py \
+      --replace "'/sbin/route'" "'${unixtools.route}/bin/route'"
+  '' + lib.optionalString stdenv.isLinux ''
+    substituteInPlace vpn_slice/linux.py \
+      --replace "'/sbin/ip'" "'${iproute2}/bin/ip'" \
+      --replace "'/sbin/iptables'" "'${iptables}/bin/iptables'"
+  '';
+
   propagatedBuildInputs = with python3Packages; [ setproctitle dnspython ];
 
   doCheck = false;