diff --git a/pkgs/development/ocaml-modules/eliom/default.nix b/pkgs/development/ocaml-modules/eliom/default.nix
index 48b9a153f5b3..73f7c0aaccd2 100644
--- a/pkgs/development/ocaml-modules/eliom/default.nix
+++ b/pkgs/development/ocaml-modules/eliom/default.nix
@@ -1,6 +1,7 @@
 { buildDunePackage
 , lib
 , fetchFromGitHub
+, fetchpatch
 , which
 , ocsigen_server
 , lwt_react
@@ -26,6 +27,12 @@ buildDunePackage rec {
     hash = "sha256-REOyxwnQqWOKywVYwN/WP22cNKZv5Nv0OpFVbNBPJN8=";
   };
 
+  # Compatibility with tyxml 4.6.x
+  patches = fetchpatch {
+    url = "https://github.com/ocsigen/eliom/commit/9a6adcce3959a37b971890999331335d07f4f732.patch";
+    hash = "sha256-rgsqohSAHHljvag3c+HNGEgW9qwmqPq8qfTpX6vVKtg=";
+  };
+
   nativeBuildInputs = [
     which
   ];
diff --git a/pkgs/development/ocaml-modules/lwd/tyxml-lwd.nix b/pkgs/development/ocaml-modules/lwd/tyxml-lwd.nix
index 0832847be3d6..0aad68fa5a0b 100644
--- a/pkgs/development/ocaml-modules/lwd/tyxml-lwd.nix
+++ b/pkgs/development/ocaml-modules/lwd/tyxml-lwd.nix
@@ -1,12 +1,17 @@
-{ lib, fetchurl, buildDunePackage, js_of_ocaml, js_of_ocaml-ppx, lwd, tyxml }:
+{ lib, fetchurl, fetchpatch, buildDunePackage, js_of_ocaml, js_of_ocaml-ppx, lwd, tyxml }:
 
 buildDunePackage {
   pname = "tyxml-lwd";
 
   inherit (lwd) version src;
 
+  # Compatibility with latest Tyxml (4.6.x)
+  patches = fetchpatch {
+    url = "https://github.com/let-def/lwd/commit/7f3364ec593b5ccf0d0294b97bcd1e28e4164691.patch";
+    hash = "sha256-W1HjExZxDKRwsrB9ZTkvHTMKO0K5iZl+FrNqPs6BPGU=";
+  };
+
   minimalOCamlVersion = "4.08";
-  duneVersion = "3";
 
   buildInputs = [ js_of_ocaml-ppx ];
   propagatedBuildInputs = [ js_of_ocaml lwd tyxml ];
diff --git a/pkgs/development/ocaml-modules/ocsigen-start/default.nix b/pkgs/development/ocaml-modules/ocsigen-start/default.nix
index 3b26c28f5341..e9af3a27a756 100644
--- a/pkgs/development/ocaml-modules/ocsigen-start/default.nix
+++ b/pkgs/development/ocaml-modules/ocsigen-start/default.nix
@@ -1,4 +1,4 @@
-{ stdenv, lib, fetchFromGitHub, ocaml, findlib, ocsigen-toolkit, pgocaml_ppx, safepass, yojson
+{ stdenv, lib, fetchFromGitHub, fetchpatch, ocaml, findlib, ocsigen-toolkit, pgocaml_ppx, safepass, yojson
 , cohttp-lwt-unix, eliom
 , resource-pooling
 , ocsigen-ppx-rpc
@@ -14,7 +14,13 @@ stdenv.mkDerivation rec {
 
   strictDeps = true;
 
-  patches = [ ./templates-dir.patch ];
+  patches = [ ./templates-dir.patch
+    # Compatibility with tyxml 4.6.x
+    (fetchpatch {
+       url = "https://github.com/ocsigen/ocsigen-start/commit/0b70506f94fcb2e06cb65ce0d6a28b9b84c695f3.patch";
+       hash = "sha256-p/VvIu9reI8lc9lxWiTrjZvn46vuF00QInYuWPtRVyk=";
+    })
+  ];
 
   src = fetchFromGitHub {
     owner = "ocsigen";
diff --git a/pkgs/development/ocaml-modules/tyxml/default.nix b/pkgs/development/ocaml-modules/tyxml/default.nix
index c49327d7d338..4cc5aa4cc42d 100644
--- a/pkgs/development/ocaml-modules/tyxml/default.nix
+++ b/pkgs/development/ocaml-modules/tyxml/default.nix
@@ -2,13 +2,11 @@
 
 buildDunePackage rec {
   pname = "tyxml";
-  version = "4.5.0";
-
-  useDune2 = true;
+  version = "4.6.0";
 
   src = fetchurl {
     url = "https://github.com/ocsigen/tyxml/releases/download/${version}/tyxml-${version}.tbz";
-    sha256 = "0s30f72m457c3gbdmdwbx7ls9zg806nvm83aiz9qkpglbppwr6n6";
+    hash = "sha256-v+tnPGtOEgpOykxIRIrdR9w/jQLCtA9j/9zMTpHJAt0=";
   };
 
   propagatedBuildInputs = [ uutf re ];