diff --git a/pkgs/applications/audio/openutau/default.nix b/pkgs/applications/audio/openutau/default.nix
index bb5c43f29fb7..f797215b607b 100644
--- a/pkgs/applications/audio/openutau/default.nix
+++ b/pkgs/applications/audio/openutau/default.nix
@@ -5,9 +5,6 @@
 , dotnetCorePackages
 , dbus
 , fontconfig
-, libICE
-, libSM
-, libX11
 , portaudio
 }:
 
@@ -32,9 +29,6 @@ buildDotnetModule rec {
 
   runtimeDeps = [
     dbus
-    libICE
-    libSM
-    libX11
     portaudio
   ];
 
diff --git a/pkgs/applications/version-management/git-credential-manager/default.nix b/pkgs/applications/version-management/git-credential-manager/default.nix
index fb70c4b71888..c9df6aff549a 100644
--- a/pkgs/applications/version-management/git-credential-manager/default.nix
+++ b/pkgs/applications/version-management/git-credential-manager/default.nix
@@ -2,21 +2,16 @@
 , fetchFromGitHub
 , buildDotnetModule
 , dotnetCorePackages
-, libX11
-, libICE
-, libSM
 , libsecret
 , git
 , git-credential-manager
 , gnupg
 , pass
 , testers
-, withGuiSupport ? true
 , withLibsecretSupport ? true
 , withGpgSupport ? true
 }:
 
-assert withLibsecretSupport -> withGuiSupport;
 buildDotnetModule rec {
   pname = "git-credential-manager";
   version = "2.5.1";
@@ -36,8 +31,7 @@ buildDotnetModule rec {
   executables = [ "git-credential-manager" ];
 
   runtimeDeps =
-    lib.optionals withGuiSupport [ libX11 libICE libSM ]
-    ++ lib.optional withLibsecretSupport libsecret;
+    lib.optional withLibsecretSupport libsecret;
   makeWrapperArgs = [
     "--prefix PATH : ${lib.makeBinPath ([ git ] ++ lib.optionals withGpgSupport [ gnupg pass ])}"
   ];
diff --git a/pkgs/build-support/dotnet/fetch-nupkg/overrides.nix b/pkgs/build-support/dotnet/fetch-nupkg/overrides.nix
index 384505a65cd2..f4bc1976e0eb 100644
--- a/pkgs/build-support/dotnet/fetch-nupkg/overrides.nix
+++ b/pkgs/build-support/dotnet/fetch-nupkg/overrides.nix
@@ -3,7 +3,11 @@
   dotnetCorePackages,
   fontconfig,
   lib,
+  libICE,
+  libSM,
+  libX11,
   stdenv,
+  writeText,
 }:
 {
   # e.g.
@@ -13,22 +17,39 @@
   #     buildInputs = old.buildInputs or [ ] ++ [ hello ];
   #   });
 
+  "Avalonia.X11" =
+    package:
+    package.overrideAttrs (
+      old:
+      lib.optionalAttrs (!stdenv.isDarwin) {
+        setupHook = writeText "setupHook.sh" ''
+          prependToVar dotnetRuntimeDeps \
+            "${lib.getLib libICE}" \
+            "${lib.getLib libSM}" \
+            "${lib.getLib libX11}"
+        '';
+      }
+    );
+
   "SkiaSharp.NativeAssets.Linux" =
     package:
-    package.overrideAttrs (old: {
-      nativeBuildInputs = old.nativeBuildInputs or [ ] ++ [ autoPatchelfHook ];
+    package.overrideAttrs (
+      old:
+      lib.optionalAttrs stdenv.isLinux {
+        nativeBuildInputs = old.nativeBuildInputs or [ ] ++ [ autoPatchelfHook ];
 
-      buildInputs = old.buildInputs or [ ] ++ [ fontconfig ];
+        buildInputs = old.buildInputs or [ ] ++ [ fontconfig ];
 
-      preInstall =
-        old.preInstall or ""
-        + ''
-          cd runtimes
-          for platform in *; do
-            [[ $platform == "${dotnetCorePackages.systemToDotnetRid stdenv.hostPlatform.system}" ]] ||
-              rm -r "$platform"
-          done
-          cd - >/dev/null
-        '';
-    });
+        preInstall =
+          old.preInstall or ""
+          + ''
+            cd runtimes
+            for platform in *; do
+              [[ $platform == "${dotnetCorePackages.systemToDotnetRid stdenv.hostPlatform.system}" ]] ||
+                rm -r "$platform"
+            done
+            cd - >/dev/null
+          '';
+      }
+    );
 }
diff --git a/pkgs/by-name/be/beatsabermodmanager/package.nix b/pkgs/by-name/be/beatsabermodmanager/package.nix
index a44d30f7fa70..e11f60c39508 100644
--- a/pkgs/by-name/be/beatsabermodmanager/package.nix
+++ b/pkgs/by-name/be/beatsabermodmanager/package.nix
@@ -5,10 +5,6 @@
 
   dotnetCorePackages,
 
-  libX11,
-  libICE,
-  libSM,
-
   xdg-utils,
 }:
 
@@ -37,11 +33,6 @@ buildDotnetModule rec {
 
   nugetDeps = ./deps.nix;
 
-  runtimeDeps = [
-    libX11
-    libICE
-    libSM
-  ];
 
   # Required for OneClick
   makeWrapperArgs = [
diff --git a/pkgs/by-name/bl/blendfarm/package.nix b/pkgs/by-name/bl/blendfarm/package.nix
index ba7bfc21af3c..4eeabc18efaf 100644
--- a/pkgs/by-name/bl/blendfarm/package.nix
+++ b/pkgs/by-name/bl/blendfarm/package.nix
@@ -6,9 +6,6 @@
   dotnetCorePackages,
   xz,
   pcre,
-  libX11,
-  libICE,
-  libSM,
   autoPatchelfHook,
   bintools,
   fixDarwinDylibNames,
@@ -77,9 +74,6 @@ buildDotnetModule rec {
   runtimeDeps = [
     xz
     pcre
-    libX11
-    libICE
-    libSM
     libgdiplus
     glib
     libXrandr
diff --git a/pkgs/by-name/kn/knossosnet/package.nix b/pkgs/by-name/kn/knossosnet/package.nix
index ab767a89300d..7abcb75f3c9a 100644
--- a/pkgs/by-name/kn/knossosnet/package.nix
+++ b/pkgs/by-name/kn/knossosnet/package.nix
@@ -3,7 +3,6 @@
   , fetchFromGitHub
   , lib
   , openal
-  , xorg
 }:
 
 buildDotnetModule rec {
@@ -22,7 +21,7 @@ buildDotnetModule rec {
   nugetDeps = ./deps.nix;
   executables = [ "Knossos.NET" ];
 
-  runtimeDeps = [ openal xorg.libX11 xorg.libICE xorg.libSM ];
+  runtimeDeps = [ openal ];
 
   meta = with lib; {
     homepage = "https://github.com/KnossosNET/Knossos.NET";
diff --git a/pkgs/by-name/li/libation/package.nix b/pkgs/by-name/li/libation/package.nix
index ff736584a33d..b84469c716fb 100644
--- a/pkgs/by-name/li/libation/package.nix
+++ b/pkgs/by-name/li/libation/package.nix
@@ -6,13 +6,6 @@
   dotnetCorePackages,
   wrapGAppsHook3,
 
-  libX11,
-  libICE,
-  libSM,
-  libXi,
-  libXcursor,
-  libXext,
-  libXrandr,
   glew,
   gtk3,
 }:
@@ -47,13 +40,6 @@ buildDotnetModule rec {
 
   runtimeDeps = [
     # For Avalonia UI
-    libX11
-    libICE
-    libSM
-    libXi
-    libXcursor
-    libXext
-    libXrandr
     glew
     # For file dialogs
     gtk3
diff --git a/pkgs/by-name/lu/lumafly/package.nix b/pkgs/by-name/lu/lumafly/package.nix
index 676b00cfa646..c15e290b465c 100644
--- a/pkgs/by-name/lu/lumafly/package.nix
+++ b/pkgs/by-name/lu/lumafly/package.nix
@@ -6,9 +6,6 @@
   zlib,
   icu,
   openssl,
-  libX11,
-  libICE,
-  libSM,
   icoutils,
   copyDesktopItems,
   makeDesktopItem,
@@ -36,9 +33,6 @@ buildDotnetModule rec {
     zlib
     icu
     openssl
-    libX11
-    libICE
-    libSM
   ];
 
   nativeBuildInputs = [
diff --git a/pkgs/by-name/ne/nexusmods-app/package.nix b/pkgs/by-name/ne/nexusmods-app/package.nix
index a55bb43e0007..6d07a5b93f9e 100644
--- a/pkgs/by-name/ne/nexusmods-app/package.nix
+++ b/pkgs/by-name/ne/nexusmods-app/package.nix
@@ -7,9 +7,6 @@
   fetchFromGitHub,
   fontconfig,
   lib,
-  libICE,
-  libSM,
-  libX11,
   runCommand,
   pname ? "nexusmods-app",
 }:
@@ -62,12 +59,6 @@ buildDotnetModule (finalAttrs: {
 
   runtimeInputs = [ desktop-file-utils ];
 
-  runtimeDeps = [
-    libICE
-    libSM
-    libX11
-  ];
-
   executables = [ "NexusMods.App" ];
 
   doCheck = true;
diff --git a/pkgs/by-name/re/retrospy/package.nix b/pkgs/by-name/re/retrospy/package.nix
index 869b6debfb1a..a207150e1e47 100644
--- a/pkgs/by-name/re/retrospy/package.nix
+++ b/pkgs/by-name/re/retrospy/package.nix
@@ -4,10 +4,6 @@
 , copyDesktopItems
 , makeDesktopItem
 , lib
-, libX11
-, libXcursor
-, libICE
-, libSM
 , runCommandLocal
 }:
 let
@@ -42,13 +38,6 @@ buildDotnetModule {
     copyDesktopItems
   ];
 
-  runtimeDeps = [
-    libX11
-    libICE
-    libXcursor
-    libSM
-  ];
-
   projectFile = [
     "RetroSpyX/RetroSpyX.csproj"
     "GBPemuX/GBPemuX.csproj"
diff --git a/pkgs/by-name/ry/ryujinx/package.nix b/pkgs/by-name/ry/ryujinx/package.nix
index cbf8e5281008..5ff91a281cd4 100644
--- a/pkgs/by-name/ry/ryujinx/package.nix
+++ b/pkgs/by-name/ry/ryujinx/package.nix
@@ -10,12 +10,6 @@
 , sndio
 , pulseaudio
 , vulkan-loader
-, libICE
-, libSM
-, libXi
-, libXcursor
-, libXext
-, libXrandr
 , glew
 , libGL
 , udev
@@ -54,12 +48,6 @@ buildDotnetModule rec {
     udev
 
     # Avalonia UI
-    libICE
-    libSM
-    libXi
-    libXcursor
-    libXext
-    libXrandr
     glew
 
     # Headless executable
diff --git a/pkgs/games/space-station-14-launcher/space-station-14-launcher.nix b/pkgs/games/space-station-14-launcher/space-station-14-launcher.nix
index 909b57277f61..10dfea3d7dee 100644
--- a/pkgs/games/space-station-14-launcher/space-station-14-launcher.nix
+++ b/pkgs/games/space-station-14-launcher/space-station-14-launcher.nix
@@ -6,13 +6,6 @@
 , iconConvTools
 , copyDesktopItems
 , makeDesktopItem
-, libX11
-, libICE
-, libSM
-, libXi
-, libXcursor
-, libXext
-, libXrandr
 , glew
 , SDL2
 , glfw
@@ -94,13 +87,6 @@ buildDotnetModule rec {
     gdk-pixbuf
 
     # Avalonia UI dependencies.
-    libX11
-    libICE
-    libSM
-    libXi
-    libXcursor
-    libXext
-    libXrandr
     glew
   ];
 
diff --git a/pkgs/tools/games/scarab/default.nix b/pkgs/tools/games/scarab/default.nix
index e3bce4d7e574..02dec25949e0 100644
--- a/pkgs/tools/games/scarab/default.nix
+++ b/pkgs/tools/games/scarab/default.nix
@@ -3,9 +3,6 @@
 , fetchFromGitHub
 , glibc
 , zlib
-, libX11
-, libICE
-, libSM
 , gtk3
 , copyDesktopItems
 , icoutils
@@ -31,9 +28,6 @@ buildDotnetModule rec {
   runtimeDeps = [
     glibc
     zlib
-    libX11
-    libICE
-    libSM
     gtk3
   ];
 
diff --git a/pkgs/tools/networking/mqttmultimeter/default.nix b/pkgs/tools/networking/mqttmultimeter/default.nix
index a265f1dfa472..29990cbc83a8 100644
--- a/pkgs/tools/networking/mqttmultimeter/default.nix
+++ b/pkgs/tools/networking/mqttmultimeter/default.nix
@@ -4,7 +4,6 @@
 , dotnet-runtime_8
 , buildDotnetModule
 , fetchFromGitHub
-, xorg
 , libglvnd
 , makeDesktopItem
 , copyDesktopItems
@@ -41,9 +40,6 @@ buildDotnetModule rec {
 
   runtimeDeps = [
     libglvnd
-    xorg.libSM
-    xorg.libICE
-    xorg.libX11
   ];
 
   desktopItems = makeDesktopItem {