diff --git a/pkgs/development/compilers/ecl/16.1.2.nix b/pkgs/development/compilers/ecl/16.1.2.nix
index bede9fa4aa68..a7b2aa6be748 100644
--- a/pkgs/development/compilers/ecl/16.1.2.nix
+++ b/pkgs/development/compilers/ecl/16.1.2.nix
@@ -61,6 +61,7 @@ stdenv.mkDerivation {
       url = "https://git.sagemath.org/sage.git/plain/build/pkgs/ecl/patches/16.1.2-getcwd.patch?id=07d6c37d18811e2b377a9689790a7c5e24da16ba";
       sha256 = "1fbi8gn7rv8nqff5mpaijsrch3k3z7qc5cn4h1vl8qrr8xwqlqhb";
     })
+    ./ecl-1.16.2-libffi-3.3-abi.patch
   ];
 
   hardeningDisable = [ "format" ];
diff --git a/pkgs/development/compilers/ecl/default.nix b/pkgs/development/compilers/ecl/default.nix
index 33ed690772ea..375b38f1dc68 100644
--- a/pkgs/development/compilers/ecl/default.nix
+++ b/pkgs/development/compilers/ecl/default.nix
@@ -35,6 +35,10 @@ stdenv.mkDerivation {
     inherit (s) url sha256;
   };
 
+  patches = [
+    ./libffi-3.3-abi.patch
+  ];
+
   configureFlags = [
     (if threadSupport then "--enable-threads" else "--disable-threads")
     "--with-gmp-prefix=${gmp.dev}"
diff --git a/pkgs/development/compilers/ecl/ecl-1.16.2-libffi-3.3-abi.patch b/pkgs/development/compilers/ecl/ecl-1.16.2-libffi-3.3-abi.patch
new file mode 100644
index 000000000000..28dd7d0805b3
--- /dev/null
+++ b/pkgs/development/compilers/ecl/ecl-1.16.2-libffi-3.3-abi.patch
@@ -0,0 +1,15 @@
+diff --git a/src/c/ffi.d b/src/c/ffi.d
+index 8861303e..8a959c23 100644
+--- a/src/c/ffi.d
++++ b/src/c/ffi.d
+@@ -145,8 +145,8 @@ static struct {
+ #elif defined(X86_WIN64)
+         {@':win64', FFI_WIN64},
+ #elif defined(X86_ANY) || defined(X86) || defined(X86_64)
+-        {@':cdecl', FFI_SYSV},
+-        {@':sysv', FFI_SYSV},
++        {@':cdecl', FFI_UNIX64},
++        {@':sysv', FFI_UNIX64},
+         {@':unix64', FFI_UNIX64},
+ #endif
+ };
diff --git a/pkgs/development/compilers/ecl/libffi-3.3-abi.patch b/pkgs/development/compilers/ecl/libffi-3.3-abi.patch
new file mode 100644
index 000000000000..0a2b5f4dd568
--- /dev/null
+++ b/pkgs/development/compilers/ecl/libffi-3.3-abi.patch
@@ -0,0 +1,15 @@
+diff --git a/src/c/ffi.d b/src/c/ffi.d
+index 8174977a..caa69f39 100644
+--- a/src/c/ffi.d
++++ b/src/c/ffi.d
+@@ -133,8 +133,8 @@ static struct {
+ #elif defined(X86_WIN64)
+   {@':win64', FFI_WIN64},
+ #elif defined(X86_ANY) || defined(X86) || defined(X86_64)
+-  {@':cdecl', FFI_SYSV},
+-  {@':sysv', FFI_SYSV},
++  {@':cdecl', FFI_UNIX64},
++  {@':sysv', FFI_UNIX64},
+   {@':unix64', FFI_UNIX64},
+ #endif
+ };