diff --git a/pkgs/development/python-modules/orange-widget-base/default.nix b/pkgs/development/python-modules/orange-widget-base/default.nix
new file mode 100644
index 000000000000..ee556ab39f77
--- /dev/null
+++ b/pkgs/development/python-modules/orange-widget-base/default.nix
@@ -0,0 +1,62 @@
+{ lib
+, stdenv
+, buildPythonPackage
+, fetchPypi
+, pyqt5
+, pyqtwebengine
+, matplotlib
+, orange-canvas-core
+, pyqtgraph
+, typing-extensions
+, qt5
+, pytestCheckHook
+, pytest-qt
+, appnope
+}:
+
+buildPythonPackage rec {
+  pname = "orange-widget-base";
+  version = "4.21.0";
+
+  src = fetchPypi {
+    inherit pname version;
+    hash = "sha256-43JeEdgEb6WS7PySW1x08fn02yl9Q/HwwKo6ojaqiH0=";
+  };
+
+  propagatedBuildInputs = [
+    matplotlib
+    orange-canvas-core
+    pyqt5
+    pyqtgraph
+    pyqtwebengine
+    typing-extensions
+  ] ++ lib.optionals stdenv.isDarwin [
+    appnope
+  ];
+
+  pythonImportsCheck = [ "orangewidget" ];
+
+  preCheck = ''
+    export HOME=$(mktemp -d)
+    export QT_PLUGIN_PATH="${qt5.qtbase.bin}/${qt5.qtbase.qtPluginPrefix}"
+    export QT_QPA_PLATFORM_PLUGIN_PATH="${qt5.qtbase.bin}/lib/qt-${qt5.qtbase.version}/plugins";
+    export QT_QPA_PLATFORM=offscreen
+  '';
+
+  nativeCheckInputs = [
+    pytest-qt
+    pytestCheckHook
+  ];
+
+  disabledTestPaths = [
+    "orangewidget/report/tests/test_report.py"
+    "orangewidget/tests/test_widget.py"
+  ];
+
+  meta = {
+    description = "Implementation of the base OWBaseWidget class and utilities for use in Orange Canvas workflows";
+    homepage = "https://github.com/biolab/orange-widget-base";
+    license = [ lib.licenses.gpl3Plus ];
+    maintainers = [ lib.maintainers.lucasew ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index d1c44492d959..3421fcae2d8e 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -7582,6 +7582,8 @@ self: super: with self; {
 
   orange-canvas-core = callPackage ../development/python-modules/orange-canvas-core { };
 
+  orange-widget-base = callPackage ../development/python-modules/orange-widget-base { };
+
   orderedmultidict = callPackage ../development/python-modules/orderedmultidict { };
 
   ordered-set = callPackage ../development/python-modules/ordered-set { };