diff --git a/pkgs/applications/audio/dexed/default.nix b/pkgs/applications/audio/dexed/default.nix
index 9bb3937cc03d..46cdb937f75e 100644
--- a/pkgs/applications/audio/dexed/default.nix
+++ b/pkgs/applications/audio/dexed/default.nix
@@ -34,7 +34,6 @@ stdenv.mkDerivation rec {
 
   postPatch = ''
     # needs special setup on Linux, dunno if it can work on Darwin
-    # https://github.com/NixOS/nixpkgs/issues/19098
     sed -i -e '/juce::juce_recommended_lto_flags/d' Source/CMakeLists.txt
   '';
 
diff --git a/pkgs/applications/audio/fire/default.nix b/pkgs/applications/audio/fire/default.nix
index 0d4691b9e4f1..5b71667a2af0 100644
--- a/pkgs/applications/audio/fire/default.nix
+++ b/pkgs/applications/audio/fire/default.nix
@@ -49,7 +49,6 @@ stdenv.mkDerivation rec {
   postPatch = ''
     # 1. Remove hardcoded LTO flags: needs extra setup on Linux,
     #    possibly broken on Darwin
-    #    https://github.com/NixOS/nixpkgs/issues/19098
     # 2. Disable automatic copying of built plugins during buildPhase, it defaults
     #    into user home and we want to have building & installing separated.
     sed -i \
diff --git a/pkgs/applications/audio/sonobus/default.nix b/pkgs/applications/audio/sonobus/default.nix
index 959c7a9d0623..fc0c5977360f 100644
--- a/pkgs/applications/audio/sonobus/default.nix
+++ b/pkgs/applications/audio/sonobus/default.nix
@@ -61,7 +61,6 @@ stdenv.mkDerivation (finalAttrs: {
 
   postPatch = lib.optionalString (stdenv.isLinux) ''
     # needs special setup on Linux, dunno if it can work on Darwin
-    # https://github.com/NixOS/nixpkgs/issues/19098
     # Also, I get issues with linking without that, not sure why
     sed -i -e '/juce::juce_recommended_lto_flags/d' CMakeLists.txt
     patchShebangs linux/install.sh
diff --git a/pkgs/applications/blockchains/miniscript/default.nix b/pkgs/applications/blockchains/miniscript/default.nix
index 84b1b55f6618..8a842d507b0c 100644
--- a/pkgs/applications/blockchains/miniscript/default.nix
+++ b/pkgs/applications/blockchains/miniscript/default.nix
@@ -18,12 +18,8 @@ stdenv.mkDerivation rec {
     postPatch = lib.optionalString stdenv.isDarwin ''
     # Replace hardcoded g++ with c++ so clang can be used
     # on darwin
-    #
-    # lto must be disabled on darwin as well due to
-    # https://github.com/NixOS/nixpkgs/issues/19098
     substituteInPlace Makefile \
-        --replace-fail 'g++' 'c++' \
-        --replace-fail '-flto' ""
+        --replace-fail 'g++' 'c++'
   '';
 
   installPhase = ''
diff --git a/pkgs/applications/emulators/firebird-emu/default.nix b/pkgs/applications/emulators/firebird-emu/default.nix
index 9fd990146161..48f364751427 100644
--- a/pkgs/applications/emulators/firebird-emu/default.nix
+++ b/pkgs/applications/emulators/firebird-emu/default.nix
@@ -19,9 +19,6 @@ stdenv.mkDerivation rec {
     hash = "sha256-ZptjlnOiF+hKuKYvBFJL95H5YQuR99d4biOco/MVEmE=";
   };
 
-  # work around https://github.com/NixOS/nixpkgs/issues/19098
-  env.NIX_CFLAGS_COMPILE = lib.optionalString (stdenv.cc.isClang && stdenv.isDarwin) "-fno-lto";
-
   nativeBuildInputs = [ wrapQtAppsHook qmake ];
 
   buildInputs = [ qtbase qtdeclarative qtquickcontrols ];
diff --git a/pkgs/applications/science/computer-architecture/timeloop/default.nix b/pkgs/applications/science/computer-architecture/timeloop/default.nix
index ec8ec3ed8abc..7fc5da8dfa89 100644
--- a/pkgs/applications/science/computer-architecture/timeloop/default.nix
+++ b/pkgs/applications/science/computer-architecture/timeloop/default.nix
@@ -41,10 +41,6 @@ stdenv.mkDerivation rec {
 
   enableParallelBuilding = true;
 
-  #link-time optimization fails on darwin
-  #see https://github.com/NixOS/nixpkgs/issues/19098
-  env.NIX_CFLAGS_COMPILE = lib.optionalString stdenv.isDarwin "-fno-lto";
-
   postPatch = ''
     # Fix gcc-13 build failure due to missing includes:
     sed -e '1i #include <cstdint>' -i \
diff --git a/pkgs/applications/virtualization/rvvm/default.nix b/pkgs/applications/virtualization/rvvm/default.nix
index ce90b686bcb0..2d6b7d3da0c5 100644
--- a/pkgs/applications/virtualization/rvvm/default.nix
+++ b/pkgs/applications/virtualization/rvvm/default.nix
@@ -38,10 +38,7 @@ stdenv.mkDerivation rec {
 
   makeFlags = [ "PREFIX=$(out)" ]
     ++ lib.optional enableSDL "USE_SDL=2" # Use SDL2 instead of SDL1
-    ++ lib.optional (!enableSDL && !enableX11) "USE_FB=0"
-
-    # work around https://github.com/NixOS/nixpkgs/issues/19098
-    ++ lib.optional (stdenv.cc.isClang && stdenv.isDarwin) "CFLAGS=-fno-lto";
+    ++ lib.optional (!enableSDL && !enableX11) "USE_FB=0";
 
   meta = with lib; {
     homepage = "https://github.com/LekKit/RVVM";
diff --git a/pkgs/by-name/tr/tracy/package.nix b/pkgs/by-name/tr/tracy/package.nix
index 82d4b9c285b8..4e462bae4a3b 100644
--- a/pkgs/by-name/tr/tracy/package.nix
+++ b/pkgs/by-name/tr/tracy/package.nix
@@ -56,9 +56,7 @@ stdenv.mkDerivation rec {
     # ../../../server/TracyView.cpp:649:34, preventing building.
     ++ lib.optional stdenv.isDarwin "-Wno-format-security"
     ++ lib.optional stdenv.isLinux "-ltbb"
-    ++ lib.optional stdenv.cc.isClang "-faligned-allocation"
-    # workaround issue #19098
-    ++ lib.optional (stdenv.cc.isClang && stdenv.isDarwin) "-fno-lto");
+    ++ lib.optional stdenv.cc.isClang "-faligned-allocation");
 
   buildPhase = ''
     runHook preBuild
diff --git a/pkgs/development/compilers/ponyc/default.nix b/pkgs/development/compilers/ponyc/default.nix
index 740ff702acd3..b10739ca3363 100644
--- a/pkgs/development/compilers/ponyc/default.nix
+++ b/pkgs/development/compilers/ponyc/default.nix
@@ -4,7 +4,7 @@
 , cmake
 , coreutils
 , libxml2
-, lto ? !stdenv.isDarwin
+, lto ? true
 , makeWrapper
 , openssl
 , pcre2
diff --git a/pkgs/development/compilers/rgbds/default.nix b/pkgs/development/compilers/rgbds/default.nix
index 4f6f0df26222..872dcae2e132 100644
--- a/pkgs/development/compilers/rgbds/default.nix
+++ b/pkgs/development/compilers/rgbds/default.nix
@@ -14,7 +14,6 @@ stdenv.mkDerivation rec {
   postPatch = ''
     patchShebangs --host src/bison.sh
   '';
-  env.NIX_CFLAGS_COMPILE = lib.optionalString stdenv.isDarwin "-fno-lto";
   installFlags = [ "PREFIX=${placeholder "out"}" ];
 
   meta = with lib; {
diff --git a/pkgs/development/interpreters/python/cpython/default.nix b/pkgs/development/interpreters/python/cpython/default.nix
index 9a155dd62b48..15c32eee3d44 100644
--- a/pkgs/development/interpreters/python/cpython/default.nix
+++ b/pkgs/development/interpreters/python/cpython/default.nix
@@ -70,8 +70,7 @@
 , enableNoSemanticInterposition ? true
 
 # enabling LTO on 32bit arch causes downstream packages to fail when linking
-# enabling LTO on *-darwin causes python3 to fail when linking.
-, enableLTO ? stdenv.is64bit && stdenv.isLinux
+, enableLTO ? stdenv.isDarwin || (stdenv.is64bit && stdenv.isLinux)
 
 # enable asserts to ensure the build remains reproducible
 , reproducibleBuild ? false
@@ -159,7 +158,7 @@ let
   ] ++ optionals (stdenv.hostPlatform != stdenv.buildPlatform) [
     buildPackages.stdenv.cc
     pythonOnBuildForHost
-  ] ++ optionals (stdenv.cc.isClang && (!stdenv.hostPlatform.useAndroidPrebuilt or false) && (enableLTO || enableOptimizations)) [
+  ] ++ optionals (stdenv.cc.isClang && !stdenv.isDarwin && (!stdenv.hostPlatform.useAndroidPrebuilt or false) && (enableLTO || enableOptimizations)) [
     stdenv.cc.cc.libllvm.out
   ];
 
diff --git a/pkgs/development/libraries/liblc3/default.nix b/pkgs/development/libraries/liblc3/default.nix
index 3e1be4ba272e..ff04d23cb0c6 100644
--- a/pkgs/development/libraries/liblc3/default.nix
+++ b/pkgs/development/libraries/liblc3/default.nix
@@ -27,9 +27,6 @@ stdenv.mkDerivation {
     ninja
   ];
 
-  # LTO does not work on Darwin: https://github.com/NixOS/nixpkgs/issues/19098
-  mesonFlags = lib.optionals stdenv.isDarwin [ "-Db_lto=false" ];
-
   meta = with lib; {
     description = "LC3 (Low Complexity Communication Codec) is an efficient low latency audio codec";
     homepage = "https://github.com/google/liblc3";
diff --git a/pkgs/development/libraries/wolfssl/default.nix b/pkgs/development/libraries/wolfssl/default.nix
index affe693fe88f..c55ad0010d53 100644
--- a/pkgs/development/libraries/wolfssl/default.nix
+++ b/pkgs/development/libraries/wolfssl/default.nix
@@ -10,7 +10,7 @@
 # requiring to build a special variant for that software. Example: 'haproxy'
 , variant ? "all"
 , extraConfigureFlags ? []
-, enableLto ? !(stdenv.isDarwin || stdenv.hostPlatform.isStatic || stdenv.cc.isClang)
+, enableLto ? !(stdenv.hostPlatform.isStatic || stdenv.cc.isClang)
 }:
 stdenv.mkDerivation (finalAttrs: {
   pname = "wolfssl-${variant}";
diff --git a/pkgs/development/python-modules/cocotb/default.nix b/pkgs/development/python-modules/cocotb/default.nix
index e7a322dad473..271ad52a9595 100644
--- a/pkgs/development/python-modules/cocotb/default.nix
+++ b/pkgs/development/python-modules/cocotb/default.nix
@@ -45,11 +45,6 @@ buildPythonPackage rec {
 
       # remove circular dependency cocotb-bus from setup.py
       substituteInPlace setup.py --replace "'cocotb-bus<1.0'" ""
-    ''
-    + lib.optionalString stdenv.isDarwin ''
-      # disable lto on darwin
-      # https://github.com/NixOS/nixpkgs/issues/19098
-      substituteInPlace cocotb_build_libs.py --replace "-flto" ""
     '';
 
   patches = [
diff --git a/pkgs/development/python-modules/levenshtein/default.nix b/pkgs/development/python-modules/levenshtein/default.nix
index a7913fd5b097..4f04a810bd5e 100644
--- a/pkgs/development/python-modules/levenshtein/default.nix
+++ b/pkgs/development/python-modules/levenshtein/default.nix
@@ -37,12 +37,6 @@ buildPythonPackage rec {
 
   buildInputs = [ rapidfuzz-cpp ];
 
-  env.NIX_CFLAGS_COMPILE = toString (
-    lib.optionals (stdenv.cc.isClang && stdenv.isDarwin) [
-      "-fno-lto" # work around https://github.com/NixOS/nixpkgs/issues/19098
-    ]
-  );
-
   dependencies = [ rapidfuzz ];
 
   nativeCheckInputs = [ pytestCheckHook ];
diff --git a/pkgs/development/python-modules/nuitka/darwin-lto.patch b/pkgs/development/python-modules/nuitka/darwin-lto.patch
deleted file mode 100644
index bd3a65905498..000000000000
--- a/pkgs/development/python-modules/nuitka/darwin-lto.patch
+++ /dev/null
@@ -1,15 +0,0 @@
-diff --git a/nuitka/build/SconsCompilerSettings.py b/nuitka/build/SconsCompilerSettings.py
-index 319b72c4e..89d40f2a2 100644
---- a/nuitka/build/SconsCompilerSettings.py
-+++ b/nuitka/build/SconsCompilerSettings.py
-@@ -173,8 +173,8 @@ def _enableLtoSettings(
-         lto_mode = False
-         reason = "known to be not supported (CondaCC)"
-     elif isMacOS() and env.gcc_mode and env.clang_mode:
--        lto_mode = True
--        reason = "known to be supported (macOS clang)"
-+        lto_mode = False
-+        reason = "known to not be supported (macOS nix clang)"
-     elif env.mingw_mode and env.clang_mode:
-         lto_mode = False
-         reason = "known to not be supported (new MinGW64 Clang)"
diff --git a/pkgs/development/python-modules/nuitka/default.nix b/pkgs/development/python-modules/nuitka/default.nix
index fa0842267031..cce4467e73e5 100644
--- a/pkgs/development/python-modules/nuitka/default.nix
+++ b/pkgs/development/python-modules/nuitka/default.nix
@@ -23,9 +23,6 @@ buildPythonPackage rec {
     hash = "sha256-nKdCMgA92v9VsSgfktXDbSh3DyKsGlcTjpn0Y7u4rxU=";
   };
 
-  # default lto off for darwin
-  patches = [ ./darwin-lto.patch ];
-
   build-system = [
     setuptools
     wheel
diff --git a/pkgs/development/python-modules/rapidfuzz/default.nix b/pkgs/development/python-modules/rapidfuzz/default.nix
index 1d406e5d3508..4fe45a1dfa44 100644
--- a/pkgs/development/python-modules/rapidfuzz/default.nix
+++ b/pkgs/development/python-modules/rapidfuzz/default.nix
@@ -59,12 +59,6 @@ buildPythonPackage rec {
       export CMAKE_ARGS="-DCMAKE_CXX_COMPILER_AR=$AR -DCMAKE_CXX_COMPILER_RANLIB=$RANLIB"
     '';
 
-  env.NIX_CFLAGS_COMPILE = toString (
-    lib.optionals (stdenv.cc.isClang && stdenv.isDarwin) [
-      "-fno-lto" # work around https://github.com/NixOS/nixpkgs/issues/19098
-    ]
-  );
-
   passthru.optional-dependencies = {
     full = [ numpy ];
   };
diff --git a/pkgs/development/ruby-modules/gem-config/default.nix b/pkgs/development/ruby-modules/gem-config/default.nix
index 2e59b8a99cc1..84d0bf21ce34 100644
--- a/pkgs/development/ruby-modules/gem-config/default.nix
+++ b/pkgs/development/ruby-modules/gem-config/default.nix
@@ -783,10 +783,7 @@ in
       substituteInPlace lib/sassc/native.rb \
         --replace 'gem_root = spec.gem_dir' 'gem_root = File.join(__dir__, "../../")'
     '';
-  } // (lib.optionalAttrs stdenv.isDarwin {
-    # https://github.com/NixOS/nixpkgs/issues/19098
-    buildFlags = [ "--disable-lto" ];
-  });
+  };
 
   sass-embedded = attrs: {
     # Patch the Rakefile to use our dart-sass and not try to fetch anything.
diff --git a/pkgs/games/eduke32/default.nix b/pkgs/games/eduke32/default.nix
index 5bb9966602d8..740d0bc47ea7 100644
--- a/pkgs/games/eduke32/default.nix
+++ b/pkgs/games/eduke32/default.nix
@@ -83,9 +83,6 @@ in stdenv.mkDerivation (finalAttrs: {
 
   makeFlags = [
     "SDLCONFIG=${SDL2}/bin/sdl2-config"
-  ] ++ lib.optionals stdenv.isDarwin [
-    # broken, see: https://github.com/NixOS/nixpkgs/issues/19098
-    "LTO=0"
   ];
 
   buildFlags = [
diff --git a/pkgs/games/stockfish/default.nix b/pkgs/games/stockfish/default.nix
index 74eff702add1..2e6d142b7148 100644
--- a/pkgs/games/stockfish/default.nix
+++ b/pkgs/games/stockfish/default.nix
@@ -30,12 +30,6 @@ stdenv.mkDerivation rec {
     sha256 = "sha256-ASy2vIP94lnSKgxixK1GoC84yAysaJpxeyuggV4MrP4=";
   };
 
-  # This addresses a linker issue with Darwin
-  # https://github.com/NixOS/nixpkgs/issues/19098
-  preBuild = lib.optionalString stdenv.isDarwin ''
-    sed -i.orig '/^\#\#\# 3.*Link Time Optimization/,/^\#\#\# 3/d' Makefile
-  '';
-
   postUnpack = ''
     sourceRoot+=/src
     echo ${nnue}
diff --git a/pkgs/tools/misc/remind/default.nix b/pkgs/tools/misc/remind/default.nix
index 51448931dcfb..4b204d5a8764 100644
--- a/pkgs/tools/misc/remind/default.nix
+++ b/pkgs/tools/misc/remind/default.nix
@@ -30,9 +30,6 @@ tcl.mkTclDerivation rec {
   '';
 
   env.NIX_CFLAGS_COMPILE = lib.optionalString stdenv.isDarwin (toString [
-    # Disable clang link time optimization until the following issue is resolved:
-    # https://github.com/NixOS/nixpkgs/issues/19098
-    "-fno-lto"
     # On Darwin setenv and unsetenv are defined in stdlib.h from libSystem
     "-DHAVE_SETENV"
     "-DHAVE_UNSETENV"
diff --git a/pkgs/tools/package-management/lix/common.nix b/pkgs/tools/package-management/lix/common.nix
index b01b381d1491..f349e06f54fe 100644
--- a/pkgs/tools/package-management/lix/common.nix
+++ b/pkgs/tools/package-management/lix/common.nix
@@ -188,7 +188,6 @@ stdenv.mkDerivation {
   mesonFlags =
     [
       # LTO optimization
-      (lib.mesonBool "b_lto" (!stdenv.isDarwin))
       (lib.mesonEnable "gc" true)
       (lib.mesonBool "enable-tests" true)
       (lib.mesonBool "enable-docs" enableDocumentation)
diff --git a/pkgs/tools/system/bfs/default.nix b/pkgs/tools/system/bfs/default.nix
index 3469060c74c5..2b714b56def5 100644
--- a/pkgs/tools/system/bfs/default.nix
+++ b/pkgs/tools/system/bfs/default.nix
@@ -13,11 +13,6 @@ stdenv.mkDerivation rec {
 
   buildInputs = [ oniguruma ] ++ lib.optionals stdenv.isLinux [ libcap acl liburing ];
 
-  # Disable LTO on darwin. See https://github.com/NixOS/nixpkgs/issues/19098
-  preConfigure = lib.optionalString stdenv.isDarwin ''
-    substituteInPlace GNUMakefile --replace "-flto=auto" ""
-  '';
-
   makeFlags = [ "PREFIX=$(out)" ];
   buildFlags = [ "release" ]; # "release" enables compiler optimizations