diff --git a/pkgs/applications/emulators/wine/base.nix b/pkgs/applications/emulators/wine/base.nix
index fc6d08556091..b290a324f970 100644
--- a/pkgs/applications/emulators/wine/base.nix
+++ b/pkgs/applications/emulators/wine/base.nix
@@ -134,7 +134,7 @@ stdenv.mkDerivation ((lib.optionalAttrs (buildScript != null) {
   configureFlags = prevConfigFlags
     ++ lib.optionals supportFlags.waylandSupport [ "--with-wayland" ]
     ++ lib.optionals supportFlags.vulkanSupport [ "--with-vulkan" ]
-    ++ lib.optionals (stdenv.isDarwin && !supportFlags.xineramaSupport) [ "--without-x" ];
+    ++ lib.optionals ((stdenv.isDarwin && !supportFlags.xineramaSupport) || !supportFlags.x11Support) [ "--without-x" ];
 
   # Wine locates a lot of libraries dynamically through dlopen().  Add
   # them to the RPATH so that the user doesn't have to set them in