diff --git a/pkgs/applications/misc/gradience/default.nix b/pkgs/applications/misc/gradience/default.nix
new file mode 100644
index 000000000000..762408097108
--- /dev/null
+++ b/pkgs/applications/misc/gradience/default.nix
@@ -0,0 +1,80 @@
+{ stdenv
+, lib
+, fetchFromGitHub
+, wrapGAppsHook4
+, meson
+, ninja
+, pkg-config
+, glib
+, desktop-file-utils
+, gettext
+, librsvg
+, blueprint-compiler
+, python3Packages
+, sassc
+, appstream-glib
+, libadwaita
+, libportal
+, libportal-gtk4
+, libsoup_3
+, gobject-introspection
+}:
+
+python3Packages.buildPythonApplication rec {
+  pname = "gradience";
+  version = "0.4.1";
+
+  src = fetchFromGitHub {
+    owner = "GradienceTeam";
+    repo = "Gradience";
+    # See https://github.com/GradienceTeam/Gradience/releases/tag/0.4.1-patch1
+    rev = "0.4.1-patch1";
+    sha256 = "sha256-5jloFbimJC4jP1C1uS8a9VlqyR5qqDuqcKvUXwr9SjY=";
+  };
+
+  format = "other";
+  dontWrapGApps = true;
+
+  nativeBuildInputs = [
+    appstream-glib
+    blueprint-compiler
+    desktop-file-utils
+    gettext
+    glib
+    gobject-introspection
+    meson
+    ninja
+    pkg-config
+    wrapGAppsHook4
+    sassc
+  ];
+
+  buildInputs = [
+    libadwaita
+    libportal
+    libportal-gtk4
+    librsvg
+    libsoup_3
+  ];
+
+  propagatedBuildInputs = with python3Packages; [
+    anyascii
+    jinja2
+    lxml
+    material-color-utilities
+    pygobject3
+    svglib
+    yapsy
+  ];
+
+  preFixup = ''
+    makeWrapperArgs+=("''${gappsWrapperArgs[@]}")
+  '';
+
+  meta = with lib; {
+    homepage = "https://github.com/GradienceTeam/Gradience";
+    description = "Customize libadwaita and GTK3 apps (with adw-gtk3)";
+    license = licenses.gpl3Plus;
+    maintainers = with maintainers; [ foo-dogsquared ];
+  };
+}
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index b12bcb93d7d9..84c238af573f 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -8039,6 +8039,8 @@ with pkgs;
 
   grafterm = callPackage ../tools/misc/grafterm { };
 
+  gradience = callPackage ../applications/misc/gradience { };
+
   grafx2 = callPackage ../applications/graphics/grafx2 { };
 
   grails = callPackage ../development/web/grails { jdk = null; };