diff --git a/pkgs/development/python-modules/highdicom/default.nix b/pkgs/development/python-modules/highdicom/default.nix
new file mode 100644
index 000000000000..b4420e6de9d4
--- /dev/null
+++ b/pkgs/development/python-modules/highdicom/default.nix
@@ -0,0 +1,79 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+, pythonOlder
+, pytestCheckHook
+, numpy
+, pillow
+, pillow-jpls
+, pydicom
+, pylibjpeg
+, pylibjpeg-libjpeg
+}:
+
+let
+  test_data = fetchFromGitHub {
+    owner = "pydicom";
+    repo = "pydicom-data";
+    rev = "cbb9b2148bccf0f550e3758c07aca3d0e328e768";
+    hash = "sha256-nF/j7pfcEpWHjjsqqTtIkW8hCEbuQ3J4IxpRk0qc1CQ=";
+  };
+in
+buildPythonPackage rec {
+  pname = "highdicom";
+  version = "0.22.0";
+  pyproject = true;
+
+  disabled = pythonOlder "3.6";
+
+  src = fetchFromGitHub {
+    owner = "MGHComputationalPathology";
+    repo = "highdicom";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-KHSJWEnm8u0xHkeeLF/U7MY4FfiWb6Q0GQQy2w1mnKw=";
+  };
+
+  propagatedBuildInputs = [
+    numpy
+    pillow
+    pillow-jpls
+    pydicom
+  ];
+
+  passthru.optional-dependencies = {
+    libjpeg = [
+      pylibjpeg
+      pylibjpeg-libjpeg
+      #pylibjpeg-openjpeg  # not in nixpkgs yet
+    ];
+  };
+
+  nativeCheckInputs = [
+    pytestCheckHook
+  ] ++ passthru.optional-dependencies.libjpeg;
+  preCheck = ''
+    export HOME=$TMP/test-home
+    mkdir -p $HOME/.pydicom/
+    ln -s ${test_data}/data_store/data $HOME/.pydicom/data
+  '';
+
+  pythonImportsCheck = [
+    "highdicom"
+    "highdicom.legacy"
+    "highdicom.ann"
+    "highdicom.ko"
+    "highdicom.pm"
+    "highdicom.pr"
+    "highdicom.seg"
+    "highdicom.sr"
+    "highdicom.sc"
+  ];
+
+  meta = with lib; {
+    description = "High-level DICOM abstractions for Python";
+    homepage = "https://highdicom.readthedocs.io";
+    changelog = "https://github.com/ImagingDataCommons/highdicom/releases/tag/v${version}";
+    license = licenses.mit;
+    maintainers = with maintainers; [ bcdarwin ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index e0770a070f22..5c1433702c0e 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -5110,6 +5110,8 @@ self: super: with self; {
 
   hickle = callPackage ../development/python-modules/hickle { };
 
+  highdicom = callPackage ../development/python-modules/highdicom { };
+
   hid = callPackage ../development/python-modules/hid {
     inherit (pkgs) hidapi;
   };