diff --git a/pkgs/applications/gis/grass/default.nix b/pkgs/applications/gis/grass/default.nix
index 5773718b0a4c..fb6c76be0794 100644
--- a/pkgs/applications/gis/grass/default.nix
+++ b/pkgs/applications/gis/grass/default.nix
@@ -12,7 +12,7 @@ stdenv.mkDerivation {
 
   buildInputs = [ flex bison zlib proj gdal libtiff libpng fftw sqlite pkgconfig cairo
   readline ffmpeg makeWrapper wxGTK30 netcdf geos postgresql mysql.client blas ]
-    ++ (with pythonPackages; [ python dateutil wxPython30 numpy sqlite3 ]);
+    ++ (with pythonPackages; [ python dateutil wxPython30 numpy ]);
 
   configureFlags = [
     "--with-proj-share=${proj}/share/proj"
diff --git a/pkgs/applications/graphics/mcomix/default.nix b/pkgs/applications/graphics/mcomix/default.nix
index c88c3337c928..20c01f77bbf8 100644
--- a/pkgs/applications/graphics/mcomix/default.nix
+++ b/pkgs/applications/graphics/mcomix/default.nix
@@ -9,7 +9,7 @@ python27Packages.buildPythonApplication rec {
       sha256 = "0fzsf9pklhfs1rzwzj64c0v30b74nk94p93h371rpg45qnfiahvy";
     };
 
-    propagatedBuildInputs = with python27Packages; [ pygtk pillow sqlite3 ];
+    propagatedBuildInputs = with python27Packages; [ pygtk pillow ];
 
     meta = {
       description = "Image viewer designed to handle comic books";
diff --git a/pkgs/applications/misc/bleachbit/default.nix b/pkgs/applications/misc/bleachbit/default.nix
index 84a122d6fd71..e67480fb3c7a 100644
--- a/pkgs/applications/misc/bleachbit/default.nix
+++ b/pkgs/applications/misc/bleachbit/default.nix
@@ -22,7 +22,7 @@ pythonPackages.buildPythonApplication rec {
     substituteInPlace $out/bin/bleachbit --replace "#!/usr/bin/env python" "#!${pythonPackages.python.interpreter}"
   '';
 
-  propagatedBuildInputs = with pythonPackages; [ pygtk sqlite3 ];
+  propagatedBuildInputs = with pythonPackages; [ pygtk ];
 
   meta = {
     homepage = "http://bleachbit.sourceforge.net";
diff --git a/pkgs/applications/misc/calibre/default.nix b/pkgs/applications/misc/calibre/default.nix
index d2e618b105b5..61e1f31a8c87 100644
--- a/pkgs/applications/misc/calibre/default.nix
+++ b/pkgs/applications/misc/calibre/default.nix
@@ -59,7 +59,7 @@ stdenv.mkDerivation rec {
     python pyqt5 sip poppler_utils libpng imagemagick libjpeg
     fontconfig podofo qtbase chmlib icu sqlite libusb1 libmtp xdg_utils
   ] ++ (with pythonPackages; [
-    apsw beautifulsoup cssselect cssutils dateutil lxml mechanize netifaces pillow sqlite3
+    apsw beautifulsoup cssselect cssutils dateutil lxml mechanize netifaces pillow
     # the following are distributed with calibre, but we use upstream instead
     chardet cherrypy html5lib odfpy routes
   ]);
diff --git a/pkgs/applications/misc/cherrytree/default.nix b/pkgs/applications/misc/cherrytree/default.nix
index 4198a9f32b25..43e41284f144 100644
--- a/pkgs/applications/misc/cherrytree/default.nix
+++ b/pkgs/applications/misc/cherrytree/default.nix
@@ -11,9 +11,6 @@ stdenv.mkDerivation rec {
     sha256 = "45f1cee4067598cf2ca8ae6f89d03789b86f9e3bf196236119868653420d7cdd";
   };
 
-  propagatedBuildInputs = with pythonPackages;
-  [ sqlite3 ];
-
   buildInputs = with pythonPackages;
   [ python gettext wrapPython pygtk dbus-python pygtksourceview ];
 
diff --git a/pkgs/applications/misc/gramps/default.nix b/pkgs/applications/misc/gramps/default.nix
index d750aea01ef0..4dcb5be8a21d 100644
--- a/pkgs/applications/misc/gramps/default.nix
+++ b/pkgs/applications/misc/gramps/default.nix
@@ -17,7 +17,7 @@ in buildPythonApplication rec {
     sha256 = "0jdps7yx2mlma1hdj64wssvnqd824xdvw0bmn2dnal5fn3h7h060";
   };
 
-  pythonPath = with pythonPackages; [ pygobject3 pycairo bsddb ] ++ [ pango ];
+  pythonPath = with pythonPackages; [ pygobject3 pycairo ] ++ [ pango ];
 
   # Same installPhase as in buildPythonApplication but without --old-and-unmanageble
   # install flag.
diff --git a/pkgs/applications/misc/hamster-time-tracker/default.nix b/pkgs/applications/misc/hamster-time-tracker/default.nix
index 3191c00e9ec9..b8bd514c9ff3 100644
--- a/pkgs/applications/misc/hamster-time-tracker/default.nix
+++ b/pkgs/applications/misc/hamster-time-tracker/default.nix
@@ -21,7 +21,7 @@ pythonPackages.buildPythonApplication rec {
     docbook2x libxslt gnome_doc_utils intltool dbus_glib hicolor_icon_theme
   ];
 
-  propagatedBuildInputs = with pythonPackages; [ pygobject2 pygtk pyxdg gnome_python dbus-python sqlite3 ];
+  propagatedBuildInputs = with pythonPackages; [ pygobject2 pygtk pyxdg gnome_python dbus-python ];
 
   configurePhase = ''
     python waf configure --prefix="$out"
diff --git a/pkgs/applications/misc/roxterm/default.nix b/pkgs/applications/misc/roxterm/default.nix
index 6473d1c25c59..738e8deb0940 100644
--- a/pkgs/applications/misc/roxterm/default.nix
+++ b/pkgs/applications/misc/roxterm/default.nix
@@ -30,7 +30,7 @@ in stdenv.mkDerivation rec {
 
   # Fix up python path so the lockfile library is on it.
   PYTHONPATH = stdenv.lib.makeSearchPathOutput "lib" python.sitePackages [
-    pythonPackages.curses pythonPackages.lockfile
+    pythonPackages.lockfile
   ];
 
   buildPhase = ''
diff --git a/pkgs/applications/networking/instant-messengers/gajim/default.nix b/pkgs/applications/networking/instant-messengers/gajim/default.nix
index cc0c07daca40..e03b99aa1718 100644
--- a/pkgs/applications/networking/instant-messengers/gajim/default.nix
+++ b/pkgs/applications/networking/instant-messengers/gajim/default.nix
@@ -61,7 +61,7 @@ stdenv.mkDerivation rec {
 
   propagatedBuildInputs = [
     pythonPackages.pygobject2 pythonPackages.pyGtkGlade
-    pythonPackages.sqlite3 pythonPackages.pyasn1
+    pythonPackages.pyasn1
     pythonPackages.pyxdg
     pythonPackages.nbxmpp
     pythonPackages.pyopenssl pythonPackages.dbus-python
diff --git a/pkgs/applications/networking/instant-messengers/pybitmessage/default.nix b/pkgs/applications/networking/instant-messengers/pybitmessage/default.nix
index 9675b5d5315a..ec4eb91d6ab1 100644
--- a/pkgs/applications/networking/instant-messengers/pybitmessage/default.nix
+++ b/pkgs/applications/networking/instant-messengers/pybitmessage/default.nix
@@ -12,7 +12,7 @@ stdenv.mkDerivation rec {
     sha256 = "1f4h0yc1mfjnxzvxiv9hxgak59mgr3a5ykv50vlyiay82za20jax";
   };
 
-  buildInputs = with pythonPackages; [ python pyqt4 wrapPython sqlite3 ] ++ [ openssl ];
+  buildInputs = with pythonPackages; [ python pyqt4 wrapPython ] ++ [ openssl ];
 
   preConfigure = ''
     substituteInPlace Makefile \
diff --git a/pkgs/applications/networking/p2p/transmission-remote-cli/default.nix b/pkgs/applications/networking/p2p/transmission-remote-cli/default.nix
index ddb37a3f64b7..fc803fa2745c 100644
--- a/pkgs/applications/networking/p2p/transmission-remote-cli/default.nix
+++ b/pkgs/applications/networking/p2p/transmission-remote-cli/default.nix
@@ -10,7 +10,6 @@ stdenv.mkDerivation rec {
   };
 
   buildInputs = with pythonPackages; [ python wrapPython ];
-  pythonPath = [ pythonPackages.curses ];
 
   installPhase = ''
     install -D transmission-remote-cli $out/bin/transmission-remote-cli
diff --git a/pkgs/applications/networking/p2p/tribler/default.nix b/pkgs/applications/networking/p2p/tribler/default.nix
index 210dbaf41c84..890271916544 100644
--- a/pkgs/applications/networking/p2p/tribler/default.nix
+++ b/pkgs/applications/networking/p2p/tribler/default.nix
@@ -21,7 +21,6 @@ stdenv.mkDerivation rec {
   pythonPath = [
     libtorrentRasterbar
     pythonPackages.wxPython
-    pythonPackages.curses
     pythonPackages.apsw
     pythonPackages.twisted
     pythonPackages.gmpy
@@ -32,7 +31,6 @@ stdenv.mkDerivation rec {
     pythonPackages.requests
     pythonPackages.setuptools
     pythonPackages.m2crypto
-    pythonPackages.sqlite3
   ];
 
   installPhase =
diff --git a/pkgs/applications/office/beancount/bean-add.nix b/pkgs/applications/office/beancount/bean-add.nix
index ca003da9c46b..3afb7ce4b10a 100644
--- a/pkgs/applications/office/beancount/bean-add.nix
+++ b/pkgs/applications/office/beancount/bean-add.nix
@@ -10,7 +10,7 @@ stdenv.mkDerivation rec {
     sha256 = "09xdsskk5rc3xsf1v1vq7nkdxrxy8w2fixx2vdv8c97ak6a4hrca";
   };
 
-  propagatedBuildInputs = with python3Packages; [ python readline ];
+  propagatedBuildInputs = with python3Packages; [ python ];
 
   installPhase = ''
     mkdir -p $out/bin/
diff --git a/pkgs/applications/office/keepnote/default.nix b/pkgs/applications/office/keepnote/default.nix
index 3f3b5c2966c5..b8d04baf356d 100644
--- a/pkgs/applications/office/keepnote/default.nix
+++ b/pkgs/applications/office/keepnote/default.nix
@@ -9,7 +9,7 @@ pythonPackages.buildPythonApplication {
     sha256 = "0nhkkv1n0lqf3zn17pxg5cgryv1wwlj4hfmhixwd76rcy8gs45dh";
   };
 
-  propagatedBuildInputs = with pythonPackages; [ sqlite3 pyGtkGlade ];
+  propagatedBuildInputs = with pythonPackages; [ pyGtkGlade ];
 
   # Testing fails.
   doCheck = false;
diff --git a/pkgs/applications/office/zim/default.nix b/pkgs/applications/office/zim/default.nix
index ec33388f0869..cda8fc63a127 100644
--- a/pkgs/applications/office/zim/default.nix
+++ b/pkgs/applications/office/zim/default.nix
@@ -17,7 +17,7 @@ pythonPackages.buildPythonApplication rec {
     sha256 = "15pdq4fxag85qjsrdmmssiq85qsk5vnbp8mrqnpvx8lm8crz6hjl";
   };
 
-  propagatedBuildInputs = with pythonPackages; [ sqlite3 pyGtkGlade pyxdg pygobject2 ];
+  propagatedBuildInputs = with pythonPackages; [ pyGtkGlade pyxdg pygobject2 ];
 
   preBuild = ''
     export HOME=$TMP
diff --git a/pkgs/applications/version-management/git-and-tools/fast-export/default.nix b/pkgs/applications/version-management/git-and-tools/fast-export/default.nix
index bb3bc806a68a..474faa30467b 100644
--- a/pkgs/applications/version-management/git-and-tools/fast-export/default.nix
+++ b/pkgs/applications/version-management/git-and-tools/fast-export/default.nix
@@ -26,7 +26,7 @@ stdenv.mkDerivation {
     mv *.py $l
     for p in $out/bin/*.sh; do
       wrapProgram $p \
-        --prefix PYTHONPATH : "$(echo ${mercurial}/lib/python*/site-packages):$(echo ${mercurial.python}/lib/python*/site-packages)${stdenv.lib.concatMapStrings (x: ":$(echo ${x}/lib/python*/site-packages)") mercurial.pythonPackages}" \
+        --prefix PYTHONPATH : "$(echo ${mercurial}/lib/python*/site-packages):$(echo ${mercurial.python}/lib/python*/site-packages)${stdenv.lib.concatMapStrings (x: ":$(echo ${x}/lib/python*/site-packages)") mercurial.pythonPackages or []}" \
         --prefix PATH : "$(dirname $(type -p python))":$l
     done
   '';
diff --git a/pkgs/applications/version-management/git-and-tools/git-remote-hg/default.nix b/pkgs/applications/version-management/git-and-tools/git-remote-hg/default.nix
index 68c680ca9798..547f5f997b98 100644
--- a/pkgs/applications/version-management/git-and-tools/git-remote-hg/default.nix
+++ b/pkgs/applications/version-management/git-and-tools/git-remote-hg/default.nix
@@ -23,7 +23,7 @@ stdenv.mkDerivation rec {
 
   postInstall = ''
     wrapProgram $out/bin/git-remote-hg \
-      --prefix PYTHONPATH : "$(echo ${mercurial}/lib/python*/site-packages):$(echo ${mercurial.python}/lib/python*/site-packages)${stdenv.lib.concatMapStrings (x: ":$(echo ${x}/lib/python*/site-packages)") mercurial.pythonPackages}"
+      --prefix PYTHONPATH : "$(echo ${mercurial}/lib/python*/site-packages):$(echo ${mercurial.python}/lib/python*/site-packages)${stdenv.lib.concatMapStrings (x: ":$(echo ${x}/lib/python*/site-packages)") mercurial.pythonPackages or []}"
   '';
 
   meta = with stdenv.lib; {
diff --git a/pkgs/applications/video/miro/default.nix b/pkgs/applications/video/miro/default.nix
index 9e08f2fffb16..0652ac7e6642 100644
--- a/pkgs/applications/video/miro/default.nix
+++ b/pkgs/applications/video/miro/default.nix
@@ -75,7 +75,7 @@ in buildPythonApplication rec {
   ];
 
   propagatedBuildInputs = with pythonPackages; [
-    pygobject2 pygtk pycurl sqlite3 mutagen pycairo dbus-python
+    pygobject2 pygtk pycurl mutagen pycairo dbus-python
     pywebkitgtk] ++ [ libtorrentRasterbar
     gst_python gst_plugins_base gst_plugins_good gst_ffmpeg
   ] ++ optional enableBonjour avahi;
diff --git a/pkgs/applications/video/pitivi/default.nix b/pkgs/applications/video/pitivi/default.nix
index d487f07e3d6d..c2c64bfa4966 100644
--- a/pkgs/applications/video/pitivi/default.nix
+++ b/pkgs/applications/video/pitivi/default.nix
@@ -42,7 +42,7 @@ in stdenv.mkDerivation rec {
     gst-plugins-base gst-plugins-good
     gst-plugins-bad gst-plugins-ugly gst-libav gst-validate
   ]) ++ (with python3Packages; [
-    python pygobject3 gst-python pyxdg numpy pycairo sqlite3 matplotlib
+    python pygobject3 gst-python pyxdg numpy pycairo matplotlib
     dbus-python
   ]);
 
diff --git a/pkgs/applications/virtualization/virt-manager/default.nix b/pkgs/applications/virtualization/virt-manager/default.nix
index 5cda21066b55..0964e1b4814b 100644
--- a/pkgs/applications/virtualization/virt-manager/default.nix
+++ b/pkgs/applications/virtualization/virt-manager/default.nix
@@ -20,7 +20,7 @@ buildPythonApplication rec {
   propagatedBuildInputs =
     [ eventlet greenlet gflags netaddr carrot routes
       PasteDeploy m2crypto ipy twisted
-      distutils_extra simplejson readline glanceclient cheetah lockfile httplib2
+      distutils_extra simplejson glanceclient cheetah lockfile httplib2
       urlgrabber virtinst pyGtkGlade dbus-python gnome_python pygobject3
       libvirt libxml2Python ipaddr vte libosinfo gobjectIntrospection gtk3 mox
       gtkvnc libvirt-glib glib gsettings_desktop_schemas gnome3.defaultIconTheme
diff --git a/pkgs/applications/virtualization/virtinst/default.nix b/pkgs/applications/virtualization/virtinst/default.nix
index 36fe43b1d3d9..04223d9a9e9d 100644
--- a/pkgs/applications/virtualization/virtinst/default.nix
+++ b/pkgs/applications/virtualization/virtinst/default.nix
@@ -15,7 +15,7 @@ stdenv.mkDerivation rec {
   pythonPath = with pythonPackages;
     [ setuptools eventlet greenlet gflags netaddr carrot routes
       PasteDeploy m2crypto ipy twisted
-      distutils_extra simplejson readline glanceclient cheetah lockfile httplib2
+      distutils_extra simplejson glanceclient cheetah lockfile httplib2
       # !!! should libvirt be a build-time dependency?  Note that
       # libxml2Python is a dependency of libvirt.py.
       libvirt libxml2Python urlgrabber
diff --git a/pkgs/applications/virtualization/xen/generic.nix b/pkgs/applications/virtualization/xen/generic.nix
index 2f65322c3563..3ebb08e4ffde 100644
--- a/pkgs/applications/virtualization/xen/generic.nix
+++ b/pkgs/applications/virtualization/xen/generic.nix
@@ -46,8 +46,6 @@ stdenv.mkDerivation {
       alsaLib quilt
     ];
 
-  pythonPath = [ pythonPackages.curses ];
-
   hardeningDisable = [ "stackprotector" "fortify" "pic" ];
 
   patches = stdenv.lib.optionals ((xenserverPatched == false) && (builtins.hasAttr "xenPatches" xenConfig)) xenConfig.xenPatches;
diff --git a/pkgs/applications/window-managers/qtile/default.nix b/pkgs/applications/window-managers/qtile/default.nix
index d170c9b74785..4b9da41b028c 100644
--- a/pkgs/applications/window-managers/qtile/default.nix
+++ b/pkgs/applications/window-managers/qtile/default.nix
@@ -31,7 +31,7 @@ python27Packages.buildPythonApplication rec {
 
   buildInputs = [ pkgconfig glib libxcb cairo pango python27Packages.xcffib ];
 
-  pythonPath = with python27Packages; [ xcffib cairocffi-xcffib trollius readline];
+  pythonPath = with python27Packages; [ xcffib cairocffi-xcffib trollius ];
 
   postInstall = ''
     wrapProgram $out/bin/qtile \
diff --git a/pkgs/games/mnemosyne/default.nix b/pkgs/games/mnemosyne/default.nix
index 0d419c08b006..c1bde5fcbc36 100644
--- a/pkgs/games/mnemosyne/default.nix
+++ b/pkgs/games/mnemosyne/default.nix
@@ -14,7 +14,6 @@ in pythonPackages.buildPythonApplication rec {
     pyqt4
     matplotlib
     cherrypy
-    sqlite3
     webob
   ];
   preConfigure = ''
diff --git a/pkgs/misc/solfege/default.nix b/pkgs/misc/solfege/default.nix
index 8e9083d99229..114e18dc93f8 100644
--- a/pkgs/misc/solfege/default.nix
+++ b/pkgs/misc/solfege/default.nix
@@ -1,5 +1,5 @@
 { stdenv, fetchurl, pkgconfig, pythonPackages, gettext, texinfo
-, ghostscript, pysqlite, librsvg, gdk_pixbuf, txt2man, timidity, mpg123
+, ghostscript, librsvg, gdk_pixbuf, txt2man, timidity, mpg123
 , alsaUtils, vorbis-tools, csound, lilypond
 , makeWrapper
 }:
@@ -15,7 +15,7 @@ in stdenv.mkDerivation rec {
   };
 
   buildInputs = [ pkgconfig python pygtk gettext texinfo
-    ghostscript pysqlite librsvg gdk_pixbuf txt2man makeWrapper
+    ghostscript librsvg gdk_pixbuf txt2man makeWrapper
   ];
 
   preBuild = ''
diff --git a/pkgs/os-specific/linux/apparmor/default.nix b/pkgs/os-specific/linux/apparmor/default.nix
index f58a7557ce35..b576ca71d580 100644
--- a/pkgs/os-specific/linux/apparmor/default.nix
+++ b/pkgs/os-specific/linux/apparmor/default.nix
@@ -82,7 +82,6 @@ let
     buildInputs = [
       perl
       pythonPackages.python
-      pythonPackages.readline
       libapparmor
       libapparmor.python
     ];
diff --git a/pkgs/os-specific/linux/iotop/default.nix b/pkgs/os-specific/linux/iotop/default.nix
index 505468d849a6..b1372e09ae52 100644
--- a/pkgs/os-specific/linux/iotop/default.nix
+++ b/pkgs/os-specific/linux/iotop/default.nix
@@ -8,8 +8,6 @@ pythonPackages.buildPythonApplication rec {
     sha256 = "0nzprs6zqax0cwq8h7hnszdl3d2m4c2d4vjfxfxbnjfs9sia5pis";
   };
 
-  propagatedBuildInputs = [ pythonPackages.curses ];
-
   doCheck = false;
 
   meta = {
diff --git a/pkgs/tools/networking/httpie/default.nix b/pkgs/tools/networking/httpie/default.nix
index c960528322bc..a3c0d47d3e74 100644
--- a/pkgs/tools/networking/httpie/default.nix
+++ b/pkgs/tools/networking/httpie/default.nix
@@ -9,7 +9,7 @@ pythonPackages.buildPythonApplication rec {
     sha256 = "0jvzxr8r6cy6ipknkw95qf8rz69nqdv5nky87h1vcp5pf8mgza1h";
   };
 
-  propagatedBuildInputs = with pythonPackages; [ pygments requests2 curses ];
+  propagatedBuildInputs = with pythonPackages; [ pygments requests2 ];
 
   doCheck = false;
 
diff --git a/pkgs/tools/networking/offlineimap/default.nix b/pkgs/tools/networking/offlineimap/default.nix
index 564eea231841..93541bd06039 100644
--- a/pkgs/tools/networking/offlineimap/default.nix
+++ b/pkgs/tools/networking/offlineimap/default.nix
@@ -1,4 +1,4 @@
-{ stdenv, fetchFromGitHub, pythonPackages, sqlite3 }:
+{ stdenv, fetchFromGitHub, pythonPackages, }:
 
 pythonPackages.buildPythonApplication rec {
   version = "7.0.6";
@@ -14,7 +14,7 @@ pythonPackages.buildPythonApplication rec {
 
   doCheck = false;
 
-  propagatedBuildInputs = [ sqlite3 pythonPackages.six ];
+  propagatedBuildInputs = [ pythonPackages.six ];
 
   meta = {
     description = "Synchronize emails between two repositories, so that you can read the same mailbox from multiple computers";
diff --git a/pkgs/tools/networking/p2p/tahoe-lafs/default.nix b/pkgs/tools/networking/p2p/tahoe-lafs/default.nix
index b01566bed075..6b88d2d2b7df 100644
--- a/pkgs/tools/networking/p2p/tahoe-lafs/default.nix
+++ b/pkgs/tools/networking/p2p/tahoe-lafs/default.nix
@@ -34,7 +34,7 @@ pythonPackages.buildPythonApplication rec {
 
   # The `backup' command requires `sqlite3'.
   propagatedBuildInputs = with pythonPackages; [
-    twisted foolscap nevow simplejson zfec pycryptopp sqlite3 darcsver
+    twisted foolscap nevow simplejson zfec pycryptopp darcsver
     setuptoolsTrial setuptoolsDarcs pycrypto pyasn1 zope_interface
     service-identity
   ];
diff --git a/pkgs/tools/networking/wicd/default.nix b/pkgs/tools/networking/wicd/default.nix
index d693b8db953a..2613fe7ab097 100644
--- a/pkgs/tools/networking/wicd/default.nix
+++ b/pkgs/tools/networking/wicd/default.nix
@@ -46,7 +46,7 @@ in stdenv.mkDerivation rec {
     sed -i "2iexport PATH=${python}/bin\$\{PATH:+:\}\$PATH" in/scripts=wicd-cli.in
     sed -i "3iexport PYTHONPATH=$(toPythonPath $out):$(toPythonPath ${pyGtkGlade})/gtk-2.0:$(toPythonPath ${pygobject2}):$(toPythonPath ${pycairo}):$(toPythonPath ${dbus-python})\$\{PYTHONPATH:+:\}\$PYTHONPATH" in/scripts=wicd-cli.in
     sed -i "2iexport PATH=${python}/bin\$\{PATH:+:\}\$PATH" in/scripts=wicd-curses.in
-    sed -i "3iexport PYTHONPATH=$(toPythonPath $out):$(toPythonPath ${pyGtkGlade})/gtk-2.0:$(toPythonPath ${pygobject2}):$(toPythonPath ${pycairo}):$(toPythonPath ${dbus-python}):$(toPythonPath ${pythonPackages.urwid}):$(toPythonPath ${pythonPackages.curses})\$\{PYTHONPATH:+:\}\$PYTHONPATH" in/scripts=wicd-curses.in
+    sed -i "3iexport PYTHONPATH=$(toPythonPath $out):$(toPythonPath ${pyGtkGlade})/gtk-2.0:$(toPythonPath ${pygobject2}):$(toPythonPath ${pycairo}):$(toPythonPath ${dbus-python}):$(toPythonPath ${pythonPackages.urwid})\$\{PYTHONPATH:+:\}\$PYTHONPATH" in/scripts=wicd-curses.in
     rm po/ast.po
   '';
 
diff --git a/pkgs/tools/package-management/nixops/generic.nix b/pkgs/tools/package-management/nixops/generic.nix
index 7948ebc43fb4..666efaecfc97 100644
--- a/pkgs/tools/package-management/nixops/generic.nix
+++ b/pkgs/tools/package-management/nixops/generic.nix
@@ -14,7 +14,6 @@ pythonPackages.buildPythonApplication {
   pythonPath =
     [ pythonPackages.prettytable
       pythonPackages.boto
-      pythonPackages.sqlite3
       pythonPackages.hetzner
       pythonPackages.libcloud
       pythonPackages.azure-storage
diff --git a/pkgs/tools/security/tor/tor-arm.nix b/pkgs/tools/security/tor/tor-arm.nix
index 1857cfcbe22e..432b1cbfceee 100644
--- a/pkgs/tools/security/tor/tor-arm.nix
+++ b/pkgs/tools/security/tor/tor-arm.nix
@@ -40,7 +40,7 @@ stdenv.mkDerivation rec {
     cp -R src/TorCtl $out/libexec
 
     wrapProgram $out/bin/arm \
-      --prefix PYTHONPATH : "$(toPythonPath $out):$(toPythonPath ${pythonPackages.curses}):$out/libexec:$PYTHONPATH" \
+      --prefix PYTHONPATH : "$(toPythonPath $out):$out/libexec:$PYTHONPATH" \
       --set TERMINFO "${ncurses.out}/share/terminfo" \
       --set TERM "xterm"
   '';
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index c0514b6c3fc4..81b03c290a93 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -2955,9 +2955,7 @@ in
 
   odt2txt = callPackage ../tools/text/odt2txt { };
 
-  offlineimap = callPackage ../tools/networking/offlineimap {
-    inherit (pythonPackages) sqlite3;
-  };
+  offlineimap = callPackage ../tools/networking/offlineimap { };
 
   oh-my-zsh = callPackage ../shells/oh-my-zsh { };
 
@@ -16918,9 +16916,7 @@ in
 
   nut = callPackage ../applications/misc/nut { };
 
-  solfege = callPackage ../misc/solfege {
-      pysqlite = pkgs.pythonPackages.sqlite3;
-  };
+  solfege = callPackage ../misc/solfege { };
 
   disnix = callPackage ../tools/package-management/disnix { };
 
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 9abcd96648a5..5f6c2e2ac885 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -901,7 +901,7 @@ in {
     windowsSupport = true;
 
     propagatedBuildInputs = with self; [
-      pycrypto paramiko jinja2 pyyaml httplib2 boto six readline
+      pycrypto paramiko jinja2 pyyaml httplib2 boto six
     ] ++ optional windowsSupport pywinrm;
 
     meta = with stdenv.lib; {
@@ -6794,7 +6794,7 @@ in {
       repo = "GateOne";
       sha256 = "1ghrawlqwv7wnck6alqpbwy9mpv0y21cw2jirrvsxaracmvgk6vv";
     };
-    propagatedBuildInputs = with self; [tornado futures html5lib readline pkgs.openssl pkgs.cacert pkgs.openssh];
+    propagatedBuildInputs = with self; [tornado futures html5lib pkgs.openssl pkgs.cacert pkgs.openssh];
     meta = {
       homepage = https://liftoffsoftware.com/;
       description = "GateOne is a web-based terminal emulator and SSH client";
@@ -15689,7 +15689,7 @@ in {
       sha256 = "1v49sym6mrci9dxy0a7cpbp4bv6fg2ijj6rwk4wzg18c2x4qzkhn";
     };
 
-    propagatedBuildInputs = with self; [ curses livestreamer ];
+    propagatedBuildInputs = with self; [ livestreamer ];
 
     meta = {
       homepage = https://github.com/gapato/livestreamer-curses;
@@ -21931,7 +21931,7 @@ in {
 
     disabled = isPy3k;
 
-    propagatedBuildInputs = with self; [ pkgs.root readline numpy matplotlib ];
+    propagatedBuildInputs = with self; [ pkgs.root numpy matplotlib ];
 
     meta = {
       homepage = "http://www.rootpy.org";
@@ -22003,7 +22003,7 @@ in {
       url = "mirror://pypi/r/ropper/${name}.tar.gz";
       sha256 = "1676e07947a19df9d17002307a7555c2647a4224d6f2869949e8fc4bd18f2e87";
     };
-    propagatedBuildInputs = with self; [ capstone filebytes readline ];
+    propagatedBuildInputs = with self; [ capstone filebytes ];
     meta = with pkgs.stdenv.lib; {
       homepage = "https://scoding.de/ropper/";
       license = licenses.gpl2;