diff --git a/pkgs/development/python-modules/elastic-apm/default.nix b/pkgs/development/python-modules/elastic-apm/default.nix
index 98e2394d0bdb..0d016b92ec3a 100644
--- a/pkgs/development/python-modules/elastic-apm/default.nix
+++ b/pkgs/development/python-modules/elastic-apm/default.nix
@@ -6,6 +6,7 @@
 , certifi
 , ecs-logging
 , fetchFromGitHub
+, fetchpatch
 , httpx
 , jinja2
 , jsonschema
@@ -40,6 +41,14 @@ buildPythonPackage rec {
     sha256 = "sha256-IaCl39rhsFLQwvQdPcqKruV/Mo3f7WH91UVgMG/cnOc=";
   };
 
+  patches = [
+    (fetchpatch {
+      # fix tests with sanic>=22.3.0
+      url = "https://github.com/elastic/apm-agent-python/commit/114ee6ca998b4d6a5cb075a289af39cb963cf08a.patch";
+      hash = "sha256-M6yEHjThKDCRQOmR0L94KEt8tUun1tPRULI6PNIlE/8=";
+    })
+  ];
+
   propagatedBuildInputs = [
     aiohttp
     blinker
diff --git a/pkgs/development/python-modules/sanic-auth/default.nix b/pkgs/development/python-modules/sanic-auth/default.nix
index c854017ae782..9e915dd66ed1 100644
--- a/pkgs/development/python-modules/sanic-auth/default.nix
+++ b/pkgs/development/python-modules/sanic-auth/default.nix
@@ -25,6 +25,11 @@ buildPythonPackage rec {
     sanic-testing
   ];
 
+  disabledTests = [
+    # incompatible with sanic>=22.3.0
+    "test_login_required"
+  ];
+
   postPatch = ''
     # Support for httpx>=0.20.0
     substituteInPlace tests/test_auth.py \
diff --git a/pkgs/development/python-modules/sanic-routing/default.nix b/pkgs/development/python-modules/sanic-routing/default.nix
index b0ecc5ed122c..cb06b5d1f2b3 100644
--- a/pkgs/development/python-modules/sanic-routing/default.nix
+++ b/pkgs/development/python-modules/sanic-routing/default.nix
@@ -7,13 +7,13 @@
 
 buildPythonPackage rec {
   pname = "sanic-routing";
-  version = "0.7.2";
+  version = "22.3.0";
 
   src = fetchFromGitHub {
     owner = "sanic-org";
     repo = "sanic-routing";
     rev = "v${version}";
-    hash = "sha256-MN6A8CtDVxj34eehr3UIwCT09VOfcruVX+/iImr1MgY=";
+    hash = "sha256-dX+uxrVjtPxX0ba3WUE/JKgj0PZzvFdKr/lXQgASN6Y=";
   };
 
   checkInputs = [ pytestCheckHook pytest-asyncio ];
diff --git a/pkgs/development/python-modules/sanic-testing/default.nix b/pkgs/development/python-modules/sanic-testing/default.nix
index 3fb60ebaa9e5..173e2b91ff79 100644
--- a/pkgs/development/python-modules/sanic-testing/default.nix
+++ b/pkgs/development/python-modules/sanic-testing/default.nix
@@ -9,13 +9,13 @@
 
 buildPythonPackage rec {
   pname = "sanic-testing";
-  version = "0.8.2";
+  version = "22.3.0";
 
   src = fetchFromGitHub {
     owner = "sanic-org";
     repo = "sanic-testing";
     rev = "v${version}";
-    sha256 = "17fbb78gvic5s9nlcgwj817fq1f9j9d1d7z6n2ahhinmvyzl9gc8";
+    sha256 = "sha256-ZsLQA8rP4RrbVSUy5n0WZs903fnF7jtFqrIe5JVuRIg=";
   };
 
   outputs = [
@@ -23,11 +23,6 @@ buildPythonPackage rec {
     "testsout"
   ];
 
-  postPatch = ''
-    substituteInPlace setup.py \
-      --replace "httpx>=0.18,<0.22" "httpx"
-  '';
-
   propagatedBuildInputs = [
     httpx
     sanic
diff --git a/pkgs/development/python-modules/sanic/default.nix b/pkgs/development/python-modules/sanic/default.nix
index ff76e2c56313..2158b96daa40 100644
--- a/pkgs/development/python-modules/sanic/default.nix
+++ b/pkgs/development/python-modules/sanic/default.nix
@@ -24,32 +24,23 @@
 
 buildPythonPackage rec {
   pname = "sanic";
-  version = "21.12.1";
+  version = "22.3.2";
   format = "setuptools";
 
-  disabled = pythonOlder "3.7" ||
-    pythonAtLeast "3.10"; # see GHSA-7p79-6x2v-5h88
+  disabled = pythonOlder "3.7";
 
   src = fetchFromGitHub {
     owner = "sanic-org";
     repo = pname;
     rev = "v${version}";
-    sha256 = "0jyl23q7b7fyqzan97qflkqcvmfpzbxbzv0qgygxasrzh80zx67g";
+    hash = "sha256-4zdPp3X22dfZ5YlW3G5/OqeUxrt+NiFO9dk2XjEKXEg=";
   };
 
   postPatch = ''
     # Loosen dependency requirements.
     substituteInPlace setup.py \
       --replace "pytest==6.2.5" "pytest" \
-      --replace "gunicorn==20.0.4" "gunicorn" \
-      --replace "multidict>=5.0,<6.0" "multidict"
-
-    sed '/pytest-sanic/d' setup.py
-
-    # Patch a request headers test to allow brotli encoding
-    # (we build httpx with brotli support, upstream doesn't).
-    substituteInPlace tests/test_headers.py \
-      --replace "deflate\r\n" "deflate, br\r\n"
+      --replace "gunicorn==20.0.4" "gunicorn"
   '';
 
   propagatedBuildInputs = [
@@ -66,8 +57,6 @@ buildPythonPackage rec {
     beautifulsoup4
     gunicorn
     pytest-asyncio
-    pytest-benchmark
-    pytest-sugar
     pytestCheckHook
     sanic-testing
     uvicorn
@@ -95,49 +84,27 @@ buildPythonPackage rec {
   ];
 
   disabledTests = [
-    # Lack of uvloop setup through fixtures
-    "test_create_asyncio_server"
-    "test_listeners_triggered_async"
-    "test_tls_options"
-    # Tests are flaky
+    # Fails to parse cmdline arguments
+    "test_dev"
+    "test_auto_reload"
+    # OSError: foo
+    "test_bad_headers"
+    "test_create_server_trigger_events"
+    "test_json_body_requests"
+    "test_missing_startup_raises_exception"
+    "test_no_body_requests"
+    "test_oserror_warning"
+    "test_running_multiple_offset_warning"
+    "test_streaming_body_requests"
+    "test_trigger_before_events_create_server"
+    "test_keep_alive_connection_context"
+    # Racy tests
     "test_keep_alive_client_timeout"
-    "test_check_timeouts_request_timeout"
-    "test_check_timeouts_response_timeout"
-    "test_reloader_live"
-    "test_zero_downtime"
-    # Not working from 21.9.1
-    "test_create_server_main"
-    "test_create_server_main_convenience"
-    "test_debug"
-    "test_auto_reload"
-    "test_no_exceptions_when_cancel_pending_request"
-    "test_ipv6_address_is_not_wrapped"
-    # Failure of the redirect tests seems to be related to httpx>0.20.0
-    "test_redirect"
-    "test_chained_redirect"
-    "test_unix_connection"
-    # These appear to be very sensitive to output of commands
-    "test_access_logs"
-    "test_auto_reload"
-    "test_host_port"
-    "test_no_exceptions_when_cancel_pending_request"
-    "test_num_workers"
-    "test_server_run"
-    "test_version"
-    # Sensitive comparison of raw HTTP header fails
-    "test_raw_headers"
-    # noisy_exceptions sometimes missing from sanic stdout
-    "test_noisy_exceptions"
-  ] ++ lib.optionals (stdenv.hostPlatform.system == "aarch64-linux") [
-    # test fail on aarch64
-    "test_tls_wrong_options"
-    "test_cookie_expires"
-    "test_gunicorn_worker"
-    "test_gunicorn_worker_no_logs"
-    "test_gunicorn_worker_with_logs"
   ];
 
   disabledTestPaths = [
+    # We are not interested in benchmarks
+    "benchmark/"
     # unable to create async loop
     "test_app.py"
     "test_asgi.py"