diff --git a/pkgs/development/libraries/itk/default.nix b/pkgs/development/libraries/itk/default.nix
index 3865aa226f9a..bb90ec4831ac 100644
--- a/pkgs/development/libraries/itk/default.nix
+++ b/pkgs/development/libraries/itk/default.nix
@@ -1,20 +1,13 @@
 { stdenv, fetchurl, fetchpatch, cmake, libX11, libuuid, xz, vtk }:
 
 stdenv.mkDerivation rec {
-  name = "itk-4.11.0";
+  name = "itk-4.12.2";
 
   src = fetchurl {
-    url = mirror://sourceforge/itk/InsightToolkit-4.11.0.tar.xz;
-    sha256 = "0axvyds0gads5914g0m70z5q16gzghr0rk0hy3qjpf1k9bkxvcq6";
+    url = mirror://sourceforge/itk/InsightToolkit-4.12.2.tar.xz;
+    sha256 = "1qw9mxbh083siljygahl4gdfv91xvfd8hfl7ghwii19f60xrvn2w";
   };
 
-  # Clang 4 dislikes signed comparisons of pointers against integers. Should no longer be
-  # necessary once we get past ITK 4.11.
-  patches = [ (fetchpatch {
-    url    = "https://github.com/InsightSoftwareConsortium/ITK/commit/d1407a55910ad9c232f3d241833cfd2e59024946.patch";
-    sha256 = "0h851afkv23fwgkibjss30fkbz4nkfg6rmmm4pfvkwpml23gzz7s";
-  }) ];
-
   cmakeFlags = [
     "-DBUILD_TESTING=OFF"
     "-DBUILD_EXAMPLES=OFF"