diff --git a/pkgs/development/python-modules/pymc/default.nix b/pkgs/development/python-modules/pymc/default.nix
index 8603eeabdee1..1f528d9ab715 100644
--- a/pkgs/development/python-modules/pymc/default.nix
+++ b/pkgs/development/python-modules/pymc/default.nix
@@ -1,6 +1,4 @@
 { lib
-, aeppl
-, aesara
 , arviz
 , buildPythonPackage
 , cachetools
@@ -8,38 +6,33 @@
 , fastprogress
 , fetchFromGitHub
 , numpy
+, pytensor
 , pythonOlder
-, pythonRelaxDepsHook
 , scipy
 , typing-extensions
 }:
 
 buildPythonPackage rec {
   pname = "pymc";
-  version = "5.0.1";
+  version = "5.0.2";
   format = "setuptools";
 
   disabled = pythonOlder "3.7";
 
   src = fetchFromGitHub {
     owner = "pymc-devs";
-    repo = "pymc";
+    repo = pname;
     rev = "refs/tags/v${version}";
-    hash = "sha256-uWvzWbZyRRE8L9X9+azmN+1JYahwwNSYCk2fQ/C8Yi0=";
+    hash = "sha256-ffNWSSzoRLFmYzN9sm5Z1j6WtEoFzGkCQxpBC0NlpRc=";
   };
 
-  nativeBuildInputs = [
-    pythonRelaxDepsHook
-  ];
-
   propagatedBuildInputs = [
-    aeppl
-    aesara
     arviz
     cachetools
     cloudpickle
     fastprogress
     numpy
+    pytensor
     scipy
     typing-extensions
   ];
@@ -49,11 +42,6 @@ buildPythonPackage rec {
       --replace ', "pytest-cov"' ""
   '';
 
-  pythonRelaxDeps = [
-    "aesara"
-    "aeppl"
-  ];
-
   # The test suite is computationally intensive and test failures are not
   # indicative for package usability hence tests are disabled by default.
   doCheck = false;
diff --git a/pkgs/development/python-modules/pytensor/default.nix b/pkgs/development/python-modules/pytensor/default.nix
new file mode 100644
index 000000000000..aed37ab14229
--- /dev/null
+++ b/pkgs/development/python-modules/pytensor/default.nix
@@ -0,0 +1,95 @@
+{ stdenv
+, lib
+, buildPythonPackage
+, cons
+, cython
+, etuples
+, fetchFromGitHub
+, filelock
+, jax
+, jaxlib
+, logical-unification
+, minikanren
+, numba
+, numba-scipy
+, numpy
+, pytestCheckHook
+, pythonOlder
+, scipy
+, typing-extensions
+}:
+
+buildPythonPackage rec {
+  pname = "pytensor";
+  version = "2.9.1";
+  format = "setuptools";
+
+  disabled = pythonOlder "3.7";
+
+  src = fetchFromGitHub {
+    owner = "pymc-devs";
+    repo = pname;
+    rev = "refs/tags/rel-${version}";
+    hash = "sha256-vuZHiDbGg55lXr9BwPT66Hy8RUe/RfYVaV57i/YlBwg=";
+  };
+
+  nativeBuildInputs = [
+    cython
+  ];
+
+  propagatedBuildInputs = [
+    cons
+    etuples
+    filelock
+    logical-unification
+    minikanren
+    numpy
+    scipy
+    typing-extensions
+  ];
+
+  checkInputs = [
+    jax
+    jaxlib
+    numba
+    numba-scipy
+    pytestCheckHook
+  ];
+
+  postPatch = ''
+    substituteInPlace setup.cfg \
+      --replace "--durations=50" ""
+  '';
+
+  preBuild = ''
+    export HOME=$(mktemp -d)
+  '';
+
+  pythonImportsCheck = [
+    "pytensor"
+  ];
+
+  disabledTests = [
+    # benchmarks (require pytest-benchmark):
+    "test_elemwise_speed"
+    "test_logsumexp_benchmark"
+    "test_scan_multiple_output"
+  ];
+
+  disabledTestPaths = [
+    # Don't run the most compute-intense tests
+    "tests/scan/"
+    "tests/tensor/"
+    "tests/sandbox/"
+    "tests/sparse/sandbox/"
+  ];
+
+  meta = with lib; {
+    description = "Python library to define, optimize, and efficiently evaluate mathematical expressions involving multi-dimensional arrays";
+    homepage = "https://github.com/pymc-devs/pytensor";
+    changelog = "https://github.com/pymc-devs/pytensor/releases";
+    license = licenses.bsd3;
+    maintainers = with maintainers; [ bcdarwin ];
+    broken = (stdenv.isLinux && stdenv.isAarch64);
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index dfe3c6d30bd0..94ed8a184db9 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8902,6 +8902,8 @@ self: super: with self; {
 
   pytenable = callPackage ../development/python-modules/pytenable { };
 
+  pytensor = callPackage ../development/python-modules/pytensor { };
+
   pytelegrambotapi = callPackage ../development/python-modules/pyTelegramBotAPI { };
 
   pytesseract = callPackage ../development/python-modules/pytesseract { };