diff --git a/pkgs/development/ocaml-modules/ppxlib/default.nix b/pkgs/development/ocaml-modules/ppxlib/default.nix
index bbaf9e27cf4d..8821e5621295 100644
--- a/pkgs/development/ocaml-modules/ppxlib/default.nix
+++ b/pkgs/development/ocaml-modules/ppxlib/default.nix
@@ -1,23 +1,30 @@
-{ stdenv, fetchFromGitHub, buildDunePackage
-, version ? "0.8.1"
+{ lib, fetchFromGitHub, buildDunePackage, ocaml
+, legacy ? false
 , ocaml-compiler-libs, ocaml-migrate-parsetree, ppx_derivers, stdio
 }:
 
-let sha256 =
-  { "0.8.1" = "0vm0jajmg8135scbg0x60ivyy5gzv4abwnl7zls2mrw23ac6kml6";
-    "0.12.0" = "1cg0is23c05k1rc94zcdz452p9zn11dpqxm1pnifwx5iygz3w0a1";
-  }."${version}"
-; in
+let param =
+  if legacy then {
+    version = "0.8.1";
+    sha256 = "0vm0jajmg8135scbg0x60ivyy5gzv4abwnl7zls2mrw23ac6kml6";
+  } else {
+    version = "0.12.0";
+    sha256 = "1cg0is23c05k1rc94zcdz452p9zn11dpqxm1pnifwx5iygz3w0a1";
+  }; in
+
+if lib.versionAtLeast ocaml.version "4.10" && legacy
+then throw "ppxlib-${param.version} is not available for OCaml ${ocaml.version}"
+else
 
 buildDunePackage rec {
   pname = "ppxlib";
-  inherit version;
+  inherit (param) version;
 
   src = fetchFromGitHub {
     owner = "ocaml-ppx";
     repo = pname;
     rev = version;
-    inherit sha256;
+    inherit (param) sha256;
   };
 
   propagatedBuildInputs = [
@@ -26,8 +33,8 @@ buildDunePackage rec {
 
   meta = {
     description = "Comprehensive ppx tool set";
-    license = stdenv.lib.licenses.mit;
-    maintainers = [ stdenv.lib.maintainers.vbgl ];
+    license = lib.licenses.mit;
+    maintainers = [ lib.maintainers.vbgl ];
     inherit (src.meta) homepage;
   };
 }
diff --git a/pkgs/top-level/ocaml-packages.nix b/pkgs/top-level/ocaml-packages.nix
index eafd45217071..2ab0e100adab 100644
--- a/pkgs/top-level/ocaml-packages.nix
+++ b/pkgs/top-level/ocaml-packages.nix
@@ -413,9 +413,7 @@ let
 
     js_of_ocaml-ppx = callPackage ../development/tools/ocaml/js_of_ocaml/ppx.nix {};
 
-    js_of_ocaml-ppx_deriving_json = callPackage ../development/tools/ocaml/js_of_ocaml/ppx_deriving_json.nix {
-      ppxlib = ppxlib.override { version = "0.12.0"; };
-    };
+    js_of_ocaml-ppx_deriving_json = callPackage ../development/tools/ocaml/js_of_ocaml/ppx_deriving_json.nix { };
 
     js_of_ocaml-tyxml = callPackage ../development/tools/ocaml/js_of_ocaml/tyxml.nix {};
 
@@ -815,7 +813,9 @@ let
 
     ppx_deriving_protobuf = callPackage ../development/ocaml-modules/ppx_deriving_protobuf {};
 
-    ppx_deriving_rpc = callPackage ../development/ocaml-modules/ppx_deriving_rpc {};
+    ppx_deriving_rpc = callPackage ../development/ocaml-modules/ppx_deriving_rpc {
+      ppxlib = ppxlib.override { legacy = true; };
+    };
 
     ppx_deriving_yojson = callPackage ../development/ocaml-modules/ppx_deriving_yojson {};
 
@@ -824,7 +824,6 @@ let
     ppx_import = callPackage ../development/ocaml-modules/ppx_import {};
 
     ppx_irmin = callPackage ../development/ocaml-modules/irmin/ppx.nix {
-      ppxlib = ppxlib.override { version = "0.12.0"; };
     };
 
     ppx_sqlexpr = callPackage ../development/ocaml-modules/sqlexpr/ppx.nix {};
@@ -965,20 +964,21 @@ let
     janeStreet =
     if lib.versionOlder "4.08" ocaml.version
     then import ../development/ocaml-modules/janestreet/0.13.nix {
-      inherit ctypes janePackage num octavius re;
+      inherit ctypes janePackage num octavius ppxlib re;
       inherit (pkgs) openssl;
-      ppxlib = ppxlib.override { version = "0.12.0"; };
     }
     else if lib.versionOlder "4.07" ocaml.version
     then import ../development/ocaml-modules/janestreet/0.12.nix {
-      inherit ctypes janePackage num octavius ppxlib re;
+      inherit ctypes janePackage num octavius re;
       inherit (pkgs) openssl;
+      ppxlib = ppxlib.override { legacy = true; };
     }
     else import ../development/ocaml-modules/janestreet {
       inherit janePackage ocamlbuild angstrom ctypes cryptokit;
       inherit magic-mime num ocaml-migrate-parsetree octavius ounit;
-      inherit ppx_deriving re ppxlib;
+      inherit ppx_deriving re;
       inherit (pkgs) openssl;
+      ppxlib = ppxlib.override { legacy = true; };
     };
 
     janeStreet_0_9_0 = import ../development/ocaml-modules/janestreet/old.nix {