diff --git a/pkgs/development/libraries/libressl/default.nix b/pkgs/development/libraries/libressl/default.nix
index 82974fe07283..000678652cad 100644
--- a/pkgs/development/libraries/libressl/default.nix
+++ b/pkgs/development/libraries/libressl/default.nix
@@ -102,4 +102,18 @@ in {
       })
     ];
   };
+
+  libressl_3_6 = generic {
+    version = "3.6.0";
+    hash = "sha256-GxLe/Lvb2+2oaSnkIQAK8PQjM63UgX/SbA2aGuxHhAQ=";
+
+    patches = [
+      # Fix endianness detection on aarch64-darwin, issue #181187
+      (fetchpatch {
+        name = "fix-endian-header-detection.patch";
+        url = "https://patch-diff.githubusercontent.com/raw/libressl-portable/portable/pull/771.patch";
+        sha256 = "sha256-in5U6+sl0HB9qMAtUL6Py4X2rlv0HsqRMIQhhM1oThE=";
+      })
+    ];
+  };
 }
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 1554e796d7f8..179ce4f08374 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -21249,9 +21249,10 @@ with pkgs;
 
   inherit (callPackages ../development/libraries/libressl { })
     libressl_3_4
-    libressl_3_5;
+    libressl_3_5
+    libressl_3_6;
 
-  libressl = libressl_3_5;
+  libressl = libressl_3_6;
 
   boringssl = callPackage ../development/libraries/boringssl { };