diff --git a/pkgs/development/python-modules/luna-usb/default.nix b/pkgs/development/python-modules/luna-usb/default.nix
new file mode 100644
index 000000000000..e5a7b44cd275
--- /dev/null
+++ b/pkgs/development/python-modules/luna-usb/default.nix
@@ -0,0 +1,75 @@
+{
+  lib,
+  fetchFromGitHub,
+  buildPythonPackage,
+  pythonOlder,
+
+  # build-system
+  setuptools,
+
+  # dependencies
+  amaranth,
+  libusb1,
+  pyserial,
+  pyusb,
+  pyvcd,
+  usb-protocol,
+
+  # tests
+  pytestCheckHook,
+  apollo-fpga,
+}:
+buildPythonPackage rec {
+  pname = "luna-usb";
+  version = "0.1.2";
+  pyproject = true;
+  disabled = pythonOlder "3.8";
+
+  src = fetchFromGitHub {
+    owner = "greatscottgadgets";
+    repo = "luna";
+    rev = "refs/tags/${version}";
+    hash = "sha256-T9V0rI6vcEpM3kN/duRni6v2plCU4B379Zx07dBGKjk=";
+  };
+
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+      --replace-fail '"setuptools-git-versioning<2"' "" \
+      --replace-fail 'dynamic = ["version"]' 'version = "${version}"'
+  '';
+
+  build-system = [
+    setuptools
+  ];
+
+  dependencies = [
+    amaranth
+    libusb1
+    pyserial
+    pyusb
+    pyvcd
+    usb-protocol
+  ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+    apollo-fpga
+  ];
+
+  pytestFlagsArray = [
+    "tests/"
+  ];
+
+  pythonImportsCheck = [
+    "luna"
+  ];
+
+  meta = {
+    changelog = "https://github.com/greatscottgadgets/luna/releases/tag/${version}";
+    description = "Amaranth HDL framework for monitoring, hacking, and developing USB devices";
+    homepage = "https://github.com/greatscottgadgets/luna";
+    license = lib.licenses.bsd3;
+    maintainers = with lib.maintainers; [ carlossless ];
+    broken = lib.versionAtLeast amaranth.version "0.5";
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 3bfa283153cb..6213343f5258 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -7610,6 +7610,8 @@ self: super: with self; {
 
   lunarcalendar = callPackage ../development/python-modules/lunarcalendar { };
 
+  luna-usb = callPackage ../development/python-modules/luna-usb { };
+
   luqum = callPackage ../development/python-modules/luqum { };
 
   luxor = callPackage ../development/python-modules/luxor { };