diff --git a/pkgs/development/libraries/db/darwin-mutexes-4.8.patch b/pkgs/development/libraries/db/darwin-mutexes-4.8.patch
new file mode 100644
index 000000000000..09d5b814f161
--- /dev/null
+++ b/pkgs/development/libraries/db/darwin-mutexes-4.8.patch
@@ -0,0 +1,55 @@
+diff -ur a/dist/aclocal/mutex.m4 b/dist/aclocal/mutex.m4
+--- a/dist/aclocal/mutex.m4	1969-12-31 19:00:01.000000000 -0500
++++ b/dist/aclocal/mutex.m4	2023-06-05 19:14:47.214158196 -0400
+@@ -372,10 +376,11 @@
+ 
+ # _spin_lock_try/_spin_unlock: Apple/Darwin
+ if test "$db_cv_mutex" = no; then
+-AC_TRY_LINK(,[
+-	int x;
+-	_spin_lock_try(&x);
+-	_spin_unlock(&x);
++AC_TRY_LINK([
++#include <os/lock.h>],[
++	os_unfair_lock x = OS_UNFAIR_LOCK_INIT;
++	bool _ = os_unfair_lock_trylock(&x);
++	os_unfair_lock_unlock(&x);
+ ], [db_cv_mutex=Darwin/_spin_lock_try])
+ fi
+ 
+diff -ur a/dbinc/mutex_int.h b/dbinc/mutex_int.h
+--- a/dbinc/mutex_int.h	1969-12-31 19:00:01.000000000 -0500
++++ b/dbinc/mutex_int.h	2023-06-05 19:15:37.510514745 -0400
+@@ -154,14 +154,13 @@
+  * Apple/Darwin library functions.
+  *********************************************************************/
+ #ifdef HAVE_MUTEX_DARWIN_SPIN_LOCK_TRY
+-typedef u_int32_t tsl_t;
++#include <os/lock.h>
++typedef os_unfair_lock tsl_t;
+ 
+ #ifdef LOAD_ACTUAL_MUTEX_CODE
+-extern int _spin_lock_try(tsl_t *);
+-extern void _spin_unlock(tsl_t *);
+-#define	MUTEX_SET(tsl)          _spin_lock_try(tsl)
+-#define	MUTEX_UNSET(tsl)        _spin_unlock(tsl)
+-#define	MUTEX_INIT(tsl)         (MUTEX_UNSET(tsl), 0)
++#define	MUTEX_SET(tsl)          os_unfair_lock_trylock(tsl)
++#define	MUTEX_UNSET(tsl)        os_unfair_lock_unlock(tsl)
++#define	MUTEX_INIT(tsl)         ({ *(tsl) = OS_UNFAIR_LOCK_INIT; tsl; })
+ #endif
+ #endif
+ 
+diff -ur a/dbinc/mutex_int.h b/dbinc/mutex_int.h
+--- a/dbinc_auto/mutex_ext.h	1969-12-31 19:00:01.000000000 -0500
++++ b/dbinc_auto/mutex_ext.h	2023-07-01 22:38:20.749201366 -0400
+@@ -34,6 +34,9 @@
+ #if !defined(HAVE_ATOMIC_SUPPORT) && defined(HAVE_MUTEX_SUPPORT)
+ atomic_value_t __atomic_dec __P((ENV *, db_atomic_t *));
+ #endif
++#if !defined(HAVE_ATOMIC_SUPPORT) && defined(HAVE_MUTEX_SUPPORT)
++int atomic_compare_exchange __P((ENV *, db_atomic_t *, atomic_value_t, atomic_value_t));
++#endif
+ int __db_pthread_mutex_init __P((ENV *, db_mutex_t, u_int32_t));
+ int __db_pthread_mutex_lock __P((ENV *, db_mutex_t));
+ #if defined(HAVE_SHARED_LATCHES)
diff --git a/pkgs/development/libraries/db/darwin-mutexes.patch b/pkgs/development/libraries/db/darwin-mutexes.patch
new file mode 100644
index 000000000000..c0616fda7f7f
--- /dev/null
+++ b/pkgs/development/libraries/db/darwin-mutexes.patch
@@ -0,0 +1,42 @@
+diff -ur a/dist/aclocal/mutex.m4 b/dist/aclocal/mutex.m4
+--- a/dist/aclocal/mutex.m4	1969-12-31 19:00:01.000000000 -0500
++++ b/dist/aclocal/mutex.m4	2023-06-05 19:14:47.214158196 -0400
+@@ -441,10 +445,11 @@
+ 
+ # _spin_lock_try/_spin_unlock: Apple/Darwin
+ if test "$db_cv_mutex" = no; then
+-AC_TRY_LINK(,[
+-	int x;
+-	_spin_lock_try(&x);
+-	_spin_unlock(&x);
++AC_TRY_LINK([
++#include <os/lock.h>],[
++	os_unfair_lock x = OS_UNFAIR_LOCK_INIT;
++	bool _ = os_unfair_lock_trylock(&x);
++	os_unfair_lock_unlock(&x);
+ ], [db_cv_mutex=Darwin/_spin_lock_try])
+ fi
+ 
+diff -ur a/src/dbinc/mutex_int.h b/src/dbinc/mutex_int.h
+--- a/src/dbinc/mutex_int.h	1969-12-31 19:00:01.000000000 -0500
++++ b/src/dbinc/mutex_int.h	2023-06-05 19:15:37.510514745 -0400
+@@ -154,14 +154,13 @@
+  * Apple/Darwin library functions.
+  *********************************************************************/
+ #ifdef HAVE_MUTEX_DARWIN_SPIN_LOCK_TRY
+-typedef u_int32_t tsl_t;
++#include <os/lock.h>
++typedef os_unfair_lock tsl_t;
+ 
+ #ifdef LOAD_ACTUAL_MUTEX_CODE
+-extern int _spin_lock_try(tsl_t *);
+-extern void _spin_unlock(tsl_t *);
+-#define	MUTEX_SET(tsl)          _spin_lock_try(tsl)
+-#define	MUTEX_UNSET(tsl)        _spin_unlock(tsl)
+-#define	MUTEX_INIT(tsl)         (MUTEX_UNSET(tsl), 0)
++#define	MUTEX_SET(tsl)          os_unfair_lock_trylock(tsl)
++#define	MUTEX_UNSET(tsl)        os_unfair_lock_unlock(tsl)
++#define	MUTEX_INIT(tsl)         ({ *(tsl) = OS_UNFAIR_LOCK_INIT; tsl; })
+ #endif
+ #endif
+
diff --git a/pkgs/development/libraries/db/db-4.8.nix b/pkgs/development/libraries/db/db-4.8.nix
index 7747751d5596..9f2a916317e4 100644
--- a/pkgs/development/libraries/db/db-4.8.nix
+++ b/pkgs/development/libraries/db/db-4.8.nix
@@ -3,7 +3,8 @@
 import ./generic.nix (args // {
   version = "4.8.30";
   sha256 = "0ampbl2f0hb1nix195kz1syrqqxpmvnvnfvphambj7xjrl3iljg0";
-  extraPatches = [ ./clang-4.8.patch ./CVE-2017-10140-4.8-cwd-db_config.patch ];
+  extraPatches = [ ./clang-4.8.patch ./CVE-2017-10140-4.8-cwd-db_config.patch ]
+    ++ lib.optionals stdenv.isDarwin [ ./darwin-mutexes-4.8.patch ];
 
   drvArgs.hardeningDisable = [ "format" ];
   drvArgs.doCheck = false;
diff --git a/pkgs/development/libraries/db/db-5.3.nix b/pkgs/development/libraries/db/db-5.3.nix
index 805f7907d6ef..3fd08c510c27 100644
--- a/pkgs/development/libraries/db/db-5.3.nix
+++ b/pkgs/development/libraries/db/db-5.3.nix
@@ -3,5 +3,6 @@
 import ./generic.nix (args // {
   version = "5.3.28";
   sha256 = "0a1n5hbl7027fbz5lm0vp0zzfp1hmxnz14wx3zl9563h83br5ag0";
-  extraPatches = [ ./clang-5.3.patch ./CVE-2017-10140-cwd-db_config.patch ];
+  extraPatches = [ ./clang-5.3.patch ./CVE-2017-10140-cwd-db_config.patch ]
+    ++ lib.optionals stdenv.isDarwin [ ./darwin-mutexes.patch ];
 })
diff --git a/pkgs/development/libraries/db/db-6.0.nix b/pkgs/development/libraries/db/db-6.0.nix
index 31091d670900..a9b748e34905 100644
--- a/pkgs/development/libraries/db/db-6.0.nix
+++ b/pkgs/development/libraries/db/db-6.0.nix
@@ -4,5 +4,6 @@ import ./generic.nix (args // {
   version = "6.0.20";
   sha256 = "00r2aaglq625y8r9xd5vw2y070plp88f1mb2gbq3kqsl7128lsl0";
   license = lib.licenses.agpl3;
-  extraPatches = [ ./clang-6.0.patch ./CVE-2017-10140-cwd-db_config.patch ];
+  extraPatches = [ ./clang-6.0.patch ./CVE-2017-10140-cwd-db_config.patch ]
+    ++ lib.optionals stdenv.isDarwin [ ./darwin-mutexes.patch ];
 })
diff --git a/pkgs/development/libraries/db/db-6.2.nix b/pkgs/development/libraries/db/db-6.2.nix
index b8c202b96376..4b3a3c6129a7 100644
--- a/pkgs/development/libraries/db/db-6.2.nix
+++ b/pkgs/development/libraries/db/db-6.2.nix
@@ -4,5 +4,6 @@ import ./generic.nix (args // {
   version = "6.2.23";
   sha256 = "1isxx4jfmnh913jzhp8hhfngbk6dsg46f4kjpvvc56maj64jqqa7";
   license = lib.licenses.agpl3;
-  extraPatches = [ ./clang-6.0.patch ./CVE-2017-10140-cwd-db_config.patch ];
+  extraPatches = [ ./clang-6.0.patch ./CVE-2017-10140-cwd-db_config.patch ]
+    ++ lib.optionals stdenv.isDarwin [ ./darwin-mutexes.patch ];
 })