diff --git a/pkgs/development/libraries/gobject-introspection/wrapper.nix b/pkgs/development/libraries/gobject-introspection/wrapper.nix
index 53b1a35f8212..5d6547a2b67d 100644
--- a/pkgs/development/libraries/gobject-introspection/wrapper.nix
+++ b/pkgs/development/libraries/gobject-introspection/wrapper.nix
@@ -94,7 +94,10 @@ else
         unwrapped = overriddenUnwrappedGir;
       };
       dontStrip = true;
-      depsTargetTargetPropagated = [ overridenTargetUnwrappedGir ];
+      # Conditional is for `pkgsCross.x86_64-freebsd.pkgsBuildHost.gobject-introspection` `error: Don't know how to run x86_64-unknown-freebsd executables.`
+      # `pkgsCross.x86_64-freebsd.buildPackages.python3.withPackages (pp: [ pp.pygobject3 ])`
+      # Using the python module does not need this propagation
+      depsTargetTargetPropagated = lib.optionals (stdenv.targetPlatform.emulatorAvailable buildPackages) [ overridenTargetUnwrappedGir ];
       buildCommand = ''
         eval fixupPhase
         ${lib.concatMapStrings (output: ''