diff --git a/pkgs/applications/blockchains/mycrypto/default.nix b/pkgs/applications/blockchains/mycrypto/default.nix
index ee7960a843ba..fd2b3347afd0 100644
--- a/pkgs/applications/blockchains/mycrypto/default.nix
+++ b/pkgs/applications/blockchains/mycrypto/default.nix
@@ -1,5 +1,4 @@
 { lib, appimageTools, fetchurl, makeDesktopItem
-, gsettings-desktop-schemas, gtk3
 }:
 
 let
@@ -29,10 +28,6 @@ let
 in appimageTools.wrapType2 rec {
   inherit name src;
 
-  profile = ''
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
-  '';
-
   multiPkgs = null; # no p32bit needed
   extraPkgs = appimageTools.defaultFhsEnvArgs.multiPkgs;
 
diff --git a/pkgs/applications/editors/standardnotes/default.nix b/pkgs/applications/editors/standardnotes/default.nix
index fa81414a7e72..e2e6bce72c41 100644
--- a/pkgs/applications/editors/standardnotes/default.nix
+++ b/pkgs/applications/editors/standardnotes/default.nix
@@ -1,5 +1,5 @@
 { lib, stdenv, appimageTools, autoPatchelfHook, desktop-file-utils
-, fetchurl, libsecret, gtk3, gsettings-desktop-schemas }:
+, fetchurl, libsecret  }:
 
 let
   version = "3.11.1";
@@ -31,10 +31,6 @@ let
 in appimageTools.wrapType2 rec {
   inherit name src;
 
-  profile = ''
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
-  '';
-
   extraPkgs = pkgs: with pkgs; [
     libsecret
   ];
diff --git a/pkgs/applications/misc/chrysalis/default.nix b/pkgs/applications/misc/chrysalis/default.nix
index 058a0f656fb5..f97d44d1ea83 100644
--- a/pkgs/applications/misc/chrysalis/default.nix
+++ b/pkgs/applications/misc/chrysalis/default.nix
@@ -1,4 +1,4 @@
-{ lib, appimageTools, fetchurl, gtk3, gsettings-desktop-schemas }:
+{ lib, appimageTools, fetchurl }:
 
 let
   pname = "chrysalis";
@@ -14,10 +14,6 @@ in appimageTools.wrapAppImage rec {
     };
   };
 
-  profile = ''
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
-  '';
-
   multiPkgs = null;
   extraPkgs = p: (appimageTools.defaultFhsEnvArgs.multiPkgs p) ++ [
     p.glib
diff --git a/pkgs/applications/misc/devdocs-desktop/default.nix b/pkgs/applications/misc/devdocs-desktop/default.nix
index 85298bc3c753..97ed9ed72962 100644
--- a/pkgs/applications/misc/devdocs-desktop/default.nix
+++ b/pkgs/applications/misc/devdocs-desktop/default.nix
@@ -1,4 +1,4 @@
-{ lib, appimageTools, fetchurl, gsettings-desktop-schemas, gtk3 }:
+{ lib, appimageTools, fetchurl }:
 
 let
   version = "0.7.2";
@@ -17,10 +17,6 @@ let
 in appimageTools.wrapType2 rec {
   inherit name src;
 
-  profile = ''
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
-  '';
-
   extraInstallCommands = ''
     mv $out/bin/${name} $out/bin/${pname}
     install -m 444 -D ${appimageContents}/devdocs.desktop $out/share/applications/devdocs.desktop
diff --git a/pkgs/applications/misc/joplin-desktop/default.nix b/pkgs/applications/misc/joplin-desktop/default.nix
index c842b7c4b36e..ecb553dbd660 100644
--- a/pkgs/applications/misc/joplin-desktop/default.nix
+++ b/pkgs/applications/misc/joplin-desktop/default.nix
@@ -1,4 +1,4 @@
-{ lib, stdenv, appimageTools, fetchurl, gsettings-desktop-schemas, gtk3, undmg }:
+{ lib, stdenv, appimageTools, fetchurl, undmg }:
 
 let
   pname = "joplin-desktop";
@@ -45,7 +45,6 @@ let
 
     profile = ''
       export LC_ALL=C.UTF-8
-      export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
     '';
 
     multiPkgs = null; # no 32bit needed
diff --git a/pkgs/applications/misc/marktext/default.nix b/pkgs/applications/misc/marktext/default.nix
index fc83e543dcfb..a99332ae82fd 100644
--- a/pkgs/applications/misc/marktext/default.nix
+++ b/pkgs/applications/misc/marktext/default.nix
@@ -1,4 +1,4 @@
-{ appimageTools, fetchurl, lib, gsettings-desktop-schemas, gtk3 }:
+{ appimageTools, fetchurl, lib }:
 
 let
   pname = "marktext";
@@ -18,12 +18,6 @@ appimageTools.wrapType2 rec {
 
   profile = ''
     export LC_ALL=C.UTF-8
-  ''
-  # Fixes file open dialog error
-  #     GLib-GIO-ERROR **: 20:36:48.243: No GSettings schemas are installed on the system
-  # See https://github.com/NixOS/nixpkgs/pull/83701#issuecomment-608034097
-  + ''
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
   '';
 
   multiPkgs = null; # no 32bit needed
diff --git a/pkgs/applications/misc/notable/default.nix b/pkgs/applications/misc/notable/default.nix
index 923f5fb4528e..9e701cdb33f6 100644
--- a/pkgs/applications/misc/notable/default.nix
+++ b/pkgs/applications/misc/notable/default.nix
@@ -1,4 +1,4 @@
-{ appimageTools, fetchurl, lib, gsettings-desktop-schemas, gtk3 }:
+{ appimageTools, fetchurl, lib }:
 
 let
   pname = "notable";
@@ -23,7 +23,6 @@ appimageTools.wrapType2 rec {
 
   profile = ''
     export LC_ALL=C.UTF-8
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
   '';
 
   multiPkgs = null; # no 32bit needed
diff --git a/pkgs/applications/misc/zettlr/default.nix b/pkgs/applications/misc/zettlr/default.nix
index d80c8d03bf43..21ac3a908d31 100644
--- a/pkgs/applications/misc/zettlr/default.nix
+++ b/pkgs/applications/misc/zettlr/default.nix
@@ -1,8 +1,6 @@
 { appimageTools
 , lib
 , fetchurl
-, gtk3
-, gsettings-desktop-schemas
 , texlive
 , pandoc
 }:
@@ -23,10 +21,6 @@ in
 appimageTools.wrapType2 rec {
   inherit name src;
 
-  profile = ''
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
-  '';
-
   multiPkgs = null; # no 32bit needed
   extraPkgs = pkgs: (appimageTools.defaultFhsEnvArgs.multiPkgs pkgs) ++ [ texlive pandoc ];
   extraInstallCommands = ''
diff --git a/pkgs/applications/networking/Sylk/default.nix b/pkgs/applications/networking/Sylk/default.nix
index c514ec22f110..18e36cb70280 100644
--- a/pkgs/applications/networking/Sylk/default.nix
+++ b/pkgs/applications/networking/Sylk/default.nix
@@ -1,4 +1,4 @@
-{ appimageTools, fetchurl, lib, gsettings-desktop-schemas, gtk3 }:
+{ appimageTools, fetchurl, lib }:
 
 let
   pname = "Sylk";
@@ -15,7 +15,6 @@ appimageTools.wrapType2 rec {
 
   profile = ''
     export LC_ALL=C.UTF-8
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
   '';
 
   multiPkgs = null; # no 32bit needed
diff --git a/pkgs/applications/networking/cluster/lens/default.nix b/pkgs/applications/networking/cluster/lens/default.nix
index 66c507312c26..151649ba22ee 100644
--- a/pkgs/applications/networking/cluster/lens/default.nix
+++ b/pkgs/applications/networking/cluster/lens/default.nix
@@ -1,4 +1,4 @@
-{ lib, fetchurl, appimageTools, wrapGAppsHook, gsettings-desktop-schemas, gtk3 }:
+{ lib, fetchurl, appimageTools, wrapGAppsHook }:
 
 let
   pname = "lens";
@@ -20,10 +20,6 @@ in
 appimageTools.wrapType2 {
   inherit name src;
 
-  profile = ''
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
-  '';
-
   extraInstallCommands =
     ''
       mv $out/bin/${name} $out/bin/${pname}
diff --git a/pkgs/applications/networking/cluster/octant/desktop.nix b/pkgs/applications/networking/cluster/octant/desktop.nix
index 1a86a66fa29b..b34e167e8c94 100644
--- a/pkgs/applications/networking/cluster/octant/desktop.nix
+++ b/pkgs/applications/networking/cluster/octant/desktop.nix
@@ -1,4 +1,4 @@
-{ lib, stdenv, appimageTools, fetchurl, gsettings-desktop-schemas, gtk3, undmg }:
+{ lib, stdenv, appimageTools, fetchurl, undmg }:
 
 let
   pname = "octant-desktop";
@@ -25,7 +25,6 @@ let
 
     profile = ''
       export LC_ALL=C.UTF-8
-      export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
     '';
 
     multiPkgs = null; # no 32bit needed
diff --git a/pkgs/applications/networking/instant-messengers/caprine-bin/build-from-appimage.nix b/pkgs/applications/networking/instant-messengers/caprine-bin/build-from-appimage.nix
index aa0a8f7bfc46..d08e1cd1ba48 100644
--- a/pkgs/applications/networking/instant-messengers/caprine-bin/build-from-appimage.nix
+++ b/pkgs/applications/networking/instant-messengers/caprine-bin/build-from-appimage.nix
@@ -1,8 +1,6 @@
 { lib
 , fetchurl
 , appimageTools
-, gtk3
-, gsettings-desktop-schemas
 , xorg
 , pname
 , version
@@ -24,7 +22,6 @@ in
 
   profile = ''
     export LC_ALL=C.UTF-8
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
   '';
 
   extraPkgs = pkgs: appimageTools.defaultFhsEnvArgs.multiPkgs pkgs;
diff --git a/pkgs/applications/networking/instant-messengers/rambox/rambox.nix b/pkgs/applications/networking/instant-messengers/rambox/rambox.nix
index d4329ed09d35..b9b5175d3b87 100644
--- a/pkgs/applications/networking/instant-messengers/rambox/rambox.nix
+++ b/pkgs/applications/networking/instant-messengers/rambox/rambox.nix
@@ -1,6 +1,6 @@
 { pname, version, src, meta, desktopName ? "Rambox" }:
 
-{ appimageTools, lib, fetchurl, gsettings-desktop-schemas, gtk3, makeDesktopItem }:
+{ appimageTools, lib, fetchurl, makeDesktopItem }:
 
 let
   name = "${pname}-${version}";
@@ -18,9 +18,6 @@ let
   };
 in appimageTools.wrapType2 rec {
   inherit name src meta;
-  profile = ''
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
-  '';
 
   extraInstallCommands = ''
     mkdir -p $out/share/applications $out/share/icons/hicolor/256x256/apps
diff --git a/pkgs/applications/networking/station/default.nix b/pkgs/applications/networking/station/default.nix
index b0e53a054d28..9409a3c5fcdd 100644
--- a/pkgs/applications/networking/station/default.nix
+++ b/pkgs/applications/networking/station/default.nix
@@ -1,4 +1,4 @@
-{ appimageTools, fetchurl, gsettings-desktop-schemas, gtk3, lib }:
+{ appimageTools, fetchurl, lib }:
 
 let
   pname = "station";
@@ -18,7 +18,6 @@ in appimageTools.wrapType2 rec {
 
   profile = ''
     export LC_ALL=C.UTF-8
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
   '';
 
   multiPkgs = null;
diff --git a/pkgs/applications/office/timeular/default.nix b/pkgs/applications/office/timeular/default.nix
index aa591c225ad0..e038749f44ed 100644
--- a/pkgs/applications/office/timeular/default.nix
+++ b/pkgs/applications/office/timeular/default.nix
@@ -2,8 +2,6 @@
 , fetchurl
 , appimageTools
 , libsecret
-, gtk3
-, gsettings-desktop-schemas
 }:
 
 let
diff --git a/pkgs/applications/office/tusk/default.nix b/pkgs/applications/office/tusk/default.nix
index f23e88a323c2..d35720672846 100644
--- a/pkgs/applications/office/tusk/default.nix
+++ b/pkgs/applications/office/tusk/default.nix
@@ -1,6 +1,4 @@
-{ appimageTools, fetchurl, lib, gsettings-desktop-schemas, gtk3
-, makeDesktopItem
-}:
+{ appimageTools, fetchurl, lib, makeDesktopItem }:
 
 let
   pname = "tusk";
@@ -31,7 +29,6 @@ in appimageTools.wrapType2 rec {
 
   profile = ''
     export LC_ALL=C.UTF-8
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
   '';
 
   multiPkgs = null; # no 32bit needed
diff --git a/pkgs/applications/version-management/git-and-tools/radicle-upstream/default.nix b/pkgs/applications/version-management/git-and-tools/radicle-upstream/default.nix
index d5791f6506cd..c88d0b9d3866 100644
--- a/pkgs/applications/version-management/git-and-tools/radicle-upstream/default.nix
+++ b/pkgs/applications/version-management/git-and-tools/radicle-upstream/default.nix
@@ -1,4 +1,4 @@
-{ lib, stdenv, appimageTools, gsettings-desktop-schemas, gtk3, autoPatchelfHook, zlib, fetchurl, undmg }:
+{ lib, stdenv, appimageTools, autoPatchelfHook, zlib, fetchurl, undmg }:
 
 let
   pname = "radicle-upstream";
@@ -39,10 +39,6 @@ let
   linux = appimageTools.wrapType2 {
     inherit name src meta;
 
-    profile = ''
-      export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
-    '';
-
     extraInstallCommands = ''
       mv $out/bin/${name} $out/bin/${pname}
 
diff --git a/pkgs/applications/video/losslesscut-bin/appimage.nix b/pkgs/applications/video/losslesscut-bin/appimage.nix
index e6be6f54e1dc..87518479db4b 100644
--- a/pkgs/applications/video/losslesscut-bin/appimage.nix
+++ b/pkgs/applications/video/losslesscut-bin/appimage.nix
@@ -1,4 +1,4 @@
-{ appimageTools, lib, fetchurl, gtk3, gsettings-desktop-schemas, version, sha256 }:
+{ appimageTools, lib, fetchurl, version, sha256 }:
 
 let
   pname = "losslesscut";
@@ -21,7 +21,6 @@ in appimageTools.wrapType2 {
 
   profile = ''
     export LC_ALL=C.UTF-8
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
   '';
 
   extraPkgs = ps: appimageTools.defaultFhsEnvArgs.multiPkgs ps;
diff --git a/pkgs/development/tools/altair-graphql-client/default.nix b/pkgs/development/tools/altair-graphql-client/default.nix
index 19650671f125..c4ead0405937 100644
--- a/pkgs/development/tools/altair-graphql-client/default.nix
+++ b/pkgs/development/tools/altair-graphql-client/default.nix
@@ -1,4 +1,4 @@
-{ lib, appimageTools, fetchurl, gsettings-desktop-schemas, gtk3 }:
+{ lib, appimageTools, fetchurl }:
 
 let
   pname = "altair";
@@ -14,10 +14,6 @@ in
 appimageTools.wrapType2 {
   inherit src pname version;
 
-  profile = ''
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
-  '';
-
   extraInstallCommands = ''
     mv $out/bin/${pname}-${version} $out/bin/${pname}
 
diff --git a/pkgs/development/tools/misc/saleae-logic-2/default.nix b/pkgs/development/tools/misc/saleae-logic-2/default.nix
index 7478c27ce9f5..a0f1b097a98a 100644
--- a/pkgs/development/tools/misc/saleae-logic-2/default.nix
+++ b/pkgs/development/tools/misc/saleae-logic-2/default.nix
@@ -1,4 +1,4 @@
-{ lib, fetchurl, makeDesktopItem, appimageTools, gtk3 }:
+{ lib, fetchurl, makeDesktopItem, appimageTools }:
 let
   name = "saleae-logic-2";
   version = "2.3.52";
@@ -31,10 +31,6 @@ appimageTools.wrapType2 {
         cp ${appimageContents}/usr/share/icons/hicolor/256x256/apps/Logic.png $out/share/pixmaps/Logic.png
       '';
 
-  profile = ''
-    export XDG_DATA_DIRS="${gtk3}/share/gsettings-schemas/${gtk3.name}''${XDG_DATA_DIRS:+:"''$XDG_DATA_DIRS"}"
-  '';
-
   extraPkgs = pkgs: with pkgs; [
     wget
     unzip
diff --git a/pkgs/development/tools/unityhub/default.nix b/pkgs/development/tools/unityhub/default.nix
index e52c38822160..4a6ca92e964b 100644
--- a/pkgs/development/tools/unityhub/default.nix
+++ b/pkgs/development/tools/unityhub/default.nix
@@ -1,4 +1,4 @@
-{ lib, fetchurl, appimageTools, gsettings-desktop-schemas, gtk3 }:
+{ lib, fetchurl, appimageTools  }:
 
 appimageTools.wrapType2 rec {
   pname = "unityhub";
@@ -31,10 +31,6 @@ appimageTools.wrapType2 rec {
         $out/share/icons/hicolor/64x64/apps/unityhub.png
     '';
 
-  profile = ''
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
-  '';
-
   meta = with lib; {
     homepage = "https://unity3d.com/";
     description = "Game development tool";
diff --git a/pkgs/development/web/bloomrpc/default.nix b/pkgs/development/web/bloomrpc/default.nix
index 1c9ed7c2e10e..59ab32131c2d 100644
--- a/pkgs/development/web/bloomrpc/default.nix
+++ b/pkgs/development/web/bloomrpc/default.nix
@@ -1,4 +1,4 @@
-{ lib, fetchurl, gsettings-desktop-schemas, gtk3, appimageTools }:
+{ lib, fetchurl, appimageTools }:
 
 let
   pname = "bloomrpc";
@@ -19,7 +19,6 @@ appimageTools.wrapType2 {
 
   profile = ''
     export LC_ALL=C.UTF-8
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
   '';
 
   multiPkgs = null; # no 32bit needed
diff --git a/pkgs/games/heroic/default.nix b/pkgs/games/heroic/default.nix
index 565bb87f7e01..044d159cde1d 100644
--- a/pkgs/games/heroic/default.nix
+++ b/pkgs/games/heroic/default.nix
@@ -1,4 +1,4 @@
-{ lib, fetchurl, appimageTools, gsettings-desktop-schemas, gtk3 }:
+{ lib, fetchurl, appimageTools }:
 
 let
   pname = "heroic";
@@ -29,10 +29,6 @@ appimageTools.wrapType2 {
       --replace 'Exec=AppRun' 'Exec=heroic'
   '';
 
-  profile = ''
-    export XDG_DATA_DIRS=${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS
-  '';
-
   meta = with lib; {
     description = "A Native GUI Epic Games Launcher for Linux, Windows and Mac";
     homepage = "https://github.com/Heroic-Games-Launcher/HeroicGamesLauncher";
diff --git a/pkgs/tools/misc/wootility/default.nix b/pkgs/tools/misc/wootility/default.nix
index a79f414a3591..cb3eeca27af8 100644
--- a/pkgs/tools/misc/wootility/default.nix
+++ b/pkgs/tools/misc/wootility/default.nix
@@ -1,8 +1,6 @@
 { appimageTools
 , fetchurl
 , lib
-, gsettings-desktop-schemas
-, gtk3
 , libxkbfile
 , udev
 , wooting-udev-rules
@@ -21,7 +19,6 @@ appimageTools.wrapType2 rec {
 
   profile = ''
     export LC_ALL=C.UTF-8
-    export XDG_DATA_DIRS="${gsettings-desktop-schemas}/share/gsettings-schemas/${gsettings-desktop-schemas.name}:${gtk3}/share/gsettings-schemas/${gtk3.name}:$XDG_DATA_DIRS"
   '';
 
   multiPkgs = extraPkgs;