diff --git a/pkgs/development/libraries/itk/5.x.nix b/pkgs/development/libraries/itk/5.x.nix
index 765b464e46a1..c3086d86ac11 100644
--- a/pkgs/development/libraries/itk/5.x.nix
+++ b/pkgs/development/libraries/itk/5.x.nix
@@ -1,5 +1,5 @@
 import ./generic.nix rec {
-  version = "5.3.0";
-  rev = "v${version}";
-  sourceSha256 = "sha256-+qCd8Jzpl5fEPTUpLyjjFBkfgCn3+Lf4pi8QnjCwofs=";
+  version = "5.4.0";
+  rev = "refs/tags/v${version}";
+  sourceSha256 = "sha256-1RSWgH0iQ2NQNsieW2m37udXWQlqYslJNM3TXC9xeP4=";
 }
diff --git a/pkgs/development/libraries/itk/generic.nix b/pkgs/development/libraries/itk/generic.nix
index be59969aaecb..54f725683a2e 100644
--- a/pkgs/development/libraries/itk/generic.nix
+++ b/pkgs/development/libraries/itk/generic.nix
@@ -38,7 +38,7 @@ stdenv.mkDerivation {
     sha256 = sourceSha256;
   };
 
-  patches = [
+  patches = lib.optionals (lib.versionOlder version "5.4") [
     (fetchpatch {
       name = "fix-gcc13-build";
       url = "https://github.com/InsightSoftwareConsortium/ITK/commit/9a719a0d2f5f489eeb9351b0ef913c3693147a4f.patch";