diff --git a/pkgs/development/libraries/libmilter/default.nix b/pkgs/development/libraries/libmilter/default.nix
index 9287b0a0dea7..38788b3c964b 100644
--- a/pkgs/development/libraries/libmilter/default.nix
+++ b/pkgs/development/libraries/libmilter/default.nix
@@ -1,4 +1,4 @@
-{ lib, stdenv, fetchurl, m4 }:
+{ lib, stdenv, fetchurl, m4, fixDarwinDylibNames }:
 
 stdenv.mkDerivation rec {
   pname = "libmilter";
@@ -34,7 +34,11 @@ stdenv.mkDerivation rec {
 
   patches = [ ./install.patch ./sharedlib.patch ./glibc-2.30.patch ./darwin.patch ];
 
-  nativeBuildInputs = [ m4 ];
+  nativeBuildInputs = [ m4 ] ++ lib.optional stdenv.isDarwin fixDarwinDylibNames;
+
+  postInstall = lib.optionalString stdenv.isDarwin ''
+    fixDarwinDylibNames $out/lib/libmilter.dylib.1
+  '';
 
   meta = with lib; {
     description = "Sendmail Milter mail filtering API library";
diff --git a/pkgs/development/python-modules/pymilter/default.nix b/pkgs/development/python-modules/pymilter/default.nix
new file mode 100644
index 000000000000..0724161bf423
--- /dev/null
+++ b/pkgs/development/python-modules/pymilter/default.nix
@@ -0,0 +1,40 @@
+{ lib, python, buildPythonPackage, fetchFromGitHub, libmilter, bsddb3, pydns, iana-etc, libredirect }:
+
+buildPythonPackage rec {
+  pname = "pymilter";
+  version = "1.0.5";
+
+  src = fetchFromGitHub {
+    owner = "sdgathman";
+    repo = pname;
+    rev = "${pname}-${version}";
+    hash = "sha256-gZUWEDVZfDRiOOdG3lpiQldHxm/93l8qYVOHOEpHhzQ=";
+  };
+
+  buildInputs = [ libmilter ];
+  propagatedBuildInputs = [ bsddb3 pydns ];
+
+  preBuild = ''
+    sed -i 's/import thread/import _thread as thread/' Milter/greylist.py
+  '';
+
+  # requires /etc/resolv.conf
+  # testpolicy: requires makemap (#100419)
+  #   using exec -a makemap smtpctl results in "unknown group smtpq"
+  preCheck = ''
+    echo "nameserver 127.0.0.1" > resolv.conf
+    export NIX_REDIRECTS=/etc/protocols=${iana-etc}/etc/protocols:/etc/resolv.conf=$(realpath resolv.conf)
+    export LD_PRELOAD=${libredirect}/lib/libredirect.so
+    sed -i '/testpolicy/d' test.py
+    rm testpolicy.py
+  '';
+
+  pythonImportsCheck = [ "Milter" ];
+
+  meta = with lib; {
+    homepage = "http://bmsi.com/python/milter.html";
+    description = "Python bindings for libmilter api";
+    maintainers = with maintainers; [ yorickvp ];
+    license = licenses.gpl2;
+  };
+}
diff --git a/pkgs/servers/mail/pypolicyd-spf/default.nix b/pkgs/servers/mail/pypolicyd-spf/default.nix
deleted file mode 100644
index cbc63ff535a1..000000000000
--- a/pkgs/servers/mail/pypolicyd-spf/default.nix
+++ /dev/null
@@ -1,26 +0,0 @@
-{ lib, buildPythonApplication, fetchurl, pyspf }:
-
-buildPythonApplication rec {
-  pname = "pypolicyd-spf";
-  majorVersion = "2.0";
-  version = "${majorVersion}.2";
-
-  src = fetchurl {
-    url = "https://launchpad.net/pypolicyd-spf/${majorVersion}/${version}/+download/${pname}-${version}.tar.gz";
-    sha256 = "1nm8y1jjgx6mxrbcxrbdnmkf8vglwp0wiw6jipzh641wb24gi76z";
-  };
-
-  propagatedBuildInputs = [ pyspf ];
-
-  preBuild = ''
-    substituteInPlace setup.py --replace "'/etc'" "'$out/etc'"
-  '';
-
-  meta = with lib; {
-    homepage = "https://launchpad.net/pypolicyd-spf/";
-    description = "Postfix policy engine for Sender Policy Framework (SPF) checking";
-    maintainers = with maintainers; [ abbradar ];
-    license = licenses.asl20;
-    platforms = platforms.all;
-  };
-}
diff --git a/pkgs/servers/mail/spf-engine/default.nix b/pkgs/servers/mail/spf-engine/default.nix
new file mode 100644
index 000000000000..0f2e98582514
--- /dev/null
+++ b/pkgs/servers/mail/spf-engine/default.nix
@@ -0,0 +1,30 @@
+{ lib, buildPythonApplication, fetchurl, pyspf, dnspython, authres, pymilter }:
+
+buildPythonApplication rec {
+  pname = "spf-engine";
+  version = "2.9.3";
+
+  src = fetchurl {
+    url = "https://launchpad.net/${pname}/${lib.versions.majorMinor version}/${version}/+download/${pname}-${version}.tar.gz";
+    sha256 = "sha256-w0Nb+L/Os3KPApENoylxCVaCD4FvgmvpfVvwCkt2IDE=";
+  };
+
+  propagatedBuildInputs = [ pyspf dnspython authres pymilter ];
+
+  pythonImportsCheck = [
+    "spf_engine"
+    "spf_engine.milter_spf"
+    "spf_engine.policyd_spf"
+  ];
+
+  postPatch = ''
+    substituteInPlace setup.py --replace "'/etc'" "'$out/etc'"
+  '';
+
+  meta = with lib; {
+    homepage = "https://launchpad.net/spf-engine/";
+    description = "Postfix policy engine for Sender Policy Framework (SPF) checking";
+    maintainers = with maintainers; [ abbradar ];
+    license = licenses.asl20;
+  };
+}
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index f944705333b3..a28f2799458b 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -1234,6 +1234,7 @@ mapAliases ({
   pyload = throw "pyload has been removed from nixpkgs, as it was unmaintained"; # Added 2021-03-21
   pynagsystemd = throw "pynagsystemd was removed as it was unmaintained and incompatible with recent systemd versions. Instead use its fork check_systemd"; # Added 2020-10-24
   pyo3-pack = maturin;
+  pypolicyd-spf = spf-engine; # Added 2022-10-09
   pyrex = throw "pyrex has been removed from nixpkgs as the project is still stuck on python2"; # Added 2022-01-12
   pyrex095 = throw "pyrex has been removed from nixpkgs as the project is still stuck on python2"; # Added 2022-01-12
   pyrex096 = throw "pyrex has been removed from nixpkgs as the project is still stuck on python2"; # Added 2022-01-12
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 3ec6c4f421b0..e104b1719d4c 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -24383,7 +24383,7 @@ with pkgs;
 
   pure-ftpd = callPackage ../servers/ftp/pure-ftpd { };
 
-  pypolicyd-spf = python3.pkgs.callPackage ../servers/mail/pypolicyd-spf { };
+  spf-engine = python3.pkgs.callPackage ../servers/mail/spf-engine { };
 
   pypiserver = with python3Packages; toPythonApplication pypiserver;
 
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index b05da5787304..d119be13e323 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -8144,6 +8144,8 @@ self: super: with self; {
 
   pymicrobot = callPackage ../development/python-modules/pymicrobot { };
 
+  pymilter = callPackage ../development/python-modules/pymilter { };
+
   pymitv = callPackage ../development/python-modules/pymitv { };
 
   pymfy = callPackage ../development/python-modules/pymfy { };