diff --git a/pkgs/build-support/cc-wrapper/default.nix b/pkgs/build-support/cc-wrapper/default.nix
index 86314c5130fb..ffb1fdc139df 100644
--- a/pkgs/build-support/cc-wrapper/default.nix
+++ b/pkgs/build-support/cc-wrapper/default.nix
@@ -45,6 +45,12 @@ let
 
   default_cxx_stdlib_compile=optionalString (targetPlatform.isLinux && !(cc.isGNU or false))
     "-isystem $(echo -n ${cc.gcc}/include/c++/*) -isystem $(echo -n ${cc.gcc}/include/c++/*)/$(${cc.gcc}/bin/gcc -dumpmachine)";
+
+  dashlessTarget = stdenv.lib.replaceStrings ["-"] ["_"] targetPlatform.config;
+  # TODO(@Ericson2314) Make unconditional
+  infixSalt  = stdenv.lib.optionalString (targetPlatform != hostPlatform) dashlessTarget;
+  infixSalt_ = stdenv.lib.optionalString (targetPlatform != hostPlatform) (dashlessTarget + "_");
+  _infixSalt = stdenv.lib.optionalString (targetPlatform != hostPlatform) ("_" + dashlessTarget);
 in
 
 stdenv.mkDerivation {
@@ -60,17 +66,17 @@ stdenv.mkDerivation {
 
   passthru = {
     inherit libc nativeTools nativeLibc nativePrefix isGNU isClang default_cxx_stdlib_compile
-            prefix;
+            prefix infixSalt infixSalt_ _infixSalt;
 
     emacsBufferSetup = pkgs: ''
       ; We should handle propagation here too
       (mapc (lambda (arg)
         (when (file-directory-p (concat arg "/include"))
-          (setenv "NIX_CFLAGS_COMPILE" (concat (getenv "NIX_CFLAGS_COMPILE") " -isystem " arg "/include")))
+          (setenv "NIX_${infixSalt_}CFLAGS_COMPILE" (concat (getenv "NIX_${infixSalt_}CFLAGS_COMPILE") " -isystem " arg "/include")))
         (when (file-directory-p (concat arg "/lib"))
-          (setenv "NIX_LDFLAGS" (concat (getenv "NIX_LDFLAGS") " -L" arg "/lib")))
+          (setenv "NIX_${infixSalt_}LDFLAGS" (concat (getenv "NIX_${infixSalt_}LDFLAGS") " -L" arg "/lib")))
         (when (file-directory-p (concat arg "/lib64"))
-          (setenv "NIX_LDFLAGS" (concat (getenv "NIX_LDFLAGS") " -L" arg "/lib64")))) '(${concatStringsSep " " (map (pkg: "\"${pkg}\"") pkgs)}))
+          (setenv "NIX_${infixSalt_}LDFLAGS" (concat (getenv "NIX_${infixSalt_}LDFLAGS") " -L" arg "/lib64")))) '(${concatStringsSep " " (map (pkg: "\"${pkg}\"") pkgs)}))
     '';
   };