diff --git a/pkgs/development/libraries/opencv/4.x.nix b/pkgs/development/libraries/opencv/4.x.nix
index 16ada2609323..c3f46d8e31ef 100644
--- a/pkgs/development/libraries/opencv/4.x.nix
+++ b/pkgs/development/libraries/opencv/4.x.nix
@@ -1,6 +1,7 @@
 { lib
 , stdenv
 , fetchurl
+, fetchpatch
 , fetchFromGitHub
 , cmake
 , pkg-config
@@ -217,6 +218,11 @@ stdenv.mkDerivation {
   # Ensures that we use the system OpenEXR rather than the vendored copy of the source included with OpenCV.
   patches = [
     ./cmake-don-t-use-OpenCVFindOpenEXR.patch
+    # Fix usage of deprecated version of protobuf' SetTotalBytesLimit. Remove with the next release.
+    (fetchpatch {
+      url = "https://github.com/opencv/opencv/commit/384875f4fcf1782b10699a379aa245a03cb27a04.patch";
+      sha256 = "1agwd0pm07m2dy8a62vmfl4n73dsmsdll2a73q6kara9wm3jlp41";
+    })
   ] ++ lib.optional enableCuda ./cuda_opt_flow.patch;
 
   # This prevents cmake from using libraries in impure paths (which